Properties of regulatory B cells regulating B cell targets.
B cell biology
basic (laboratory) research / science
cellular biology
flow cytometry
immune regulation
immunobiology
immunosuppression / immune modulation
translational research / science
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
09
07
2021
received:
05
02
2021
accepted:
21
07
2021
pubmed:
31
7
2021
medline:
1
2
2022
entrez:
30
7
2021
Statut:
ppublish
Résumé
Regulatory B cells (Bregs) have shown promise as anti-rejection therapy applied to organ transplantation. However, less is known about their effect on other B cell populations that are involved in chronic graft rejection. We recently uncovered that naïve B cells, stimulated by TLR ligand agonists, converted into B cells with regulatory properties (Bregs-TLR) that prevented allograft rejection. Here, we examine the granular phenotype and regulatory properties of Breg-TLR cells suppressing B cells. Cocultures of Bregs-TLR with LPS-activated B cells showed a dose-dependent suppression of targeted B cell proliferation. Adoptive transfers of Bregs-TLR induced a decline in antibody responses to antigenically disparate skin grafts. The role of Breg BCR specificity in regulation was assessed using B cell-deficient mice replenished with transgenic BCR (OB1) and TCR (OT-II) lymphocytes of matching antigenic specificity. Results indicated that proliferation of OB1 B cells, mediated through help from CD4
Identifiants
pubmed: 34327838
doi: 10.1111/ajt.16772
pmc: PMC8639638
mid: NIHMS1734854
pii: S1600-6135(22)08833-5
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3847-3857Subventions
Organisme : NIAID NIH HHS
ID : R01 AI057851
Pays : United States
Informations de copyright
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.
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