Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2.
Agrimonia
/ chemistry
Amino Acid Sequence
Antiviral Agents
/ chemistry
Biological Products
/ chemistry
Drug Discovery
Humans
Hydrolyzable Tannins
/ chemistry
Molecular Docking Simulation
Plant Extracts
/ chemistry
Protein Binding
Quercetin
/ chemistry
SARS-CoV-2
/ drug effects
Spike Glycoprotein, Coronavirus
/ chemistry
Triterpenes
/ chemistry
Virus Internalization
/ drug effects
COVID-19 Drug Treatment
Ursolic Acid
APRG64
Agrimonia pilosa
Antiviral agents
COVID-19
Galla rhois
SARS-CoV-2
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
18
04
2021
revised:
17
07
2021
accepted:
19
07
2021
pubmed:
31
7
2021
medline:
8
9
2021
entrez:
30
7
2021
Statut:
ppublish
Résumé
Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-d-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.
Identifiants
pubmed: 34329818
pii: S0968-0896(21)00337-0
doi: 10.1016/j.bmc.2021.116329
pmc: PMC8299292
pii:
doi:
Substances chimiques
Antiviral Agents
0
Biological Products
0
Galla Rhois
0
Hydrolyzable Tannins
0
Plant Extracts
0
Spike Glycoprotein, Coronavirus
0
Triterpenes
0
spike protein, SARS-CoV-2
0
pentagalloylglucose
3UI3K8W93I
Quercetin
9IKM0I5T1E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116329Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
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