Evaluation of the influence of diet supplementation with conjugated linoleic acid isomers on elemental composition in the cardio-oncological nutritional programming rat' model.
Breast cancer
Conjugated linoleic acid
Elements
Heart
Nutritional programming
Rats
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
20
05
2020
revised:
17
05
2021
accepted:
03
07
2021
pubmed:
31
7
2021
medline:
17
2
2022
entrez:
30
7
2021
Statut:
ppublish
Résumé
The 'developmental origin of health and disease' (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal' and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer. Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). The effect of maternal' diet on the elements content was more pronounced than the progeny diet modifications. Significant correlations among determined elements, especially macroelements, and lipidomic parameters, in the experimental factors dependent manner were observed. It can be concluded that supplementation of maternal and progeny diets with CLA isomers may significantly influence the contents of both macro- and microelements in cardiac tissue of newborns. Our results also indicate, that dynamic and intricate balance among various elements in body may be affected by the lipid dietary supplements also in the pathological state. Utility of cardio-oncological approach in developmental programming study was confirmed.
Sections du résumé
BACKGROUND
BACKGROUND
The 'developmental origin of health and disease' (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal' and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer.
METHODS
METHODS
Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS).
RESULTS
RESULTS
The effect of maternal' diet on the elements content was more pronounced than the progeny diet modifications. Significant correlations among determined elements, especially macroelements, and lipidomic parameters, in the experimental factors dependent manner were observed. It can be concluded that supplementation of maternal and progeny diets with CLA isomers may significantly influence the contents of both macro- and microelements in cardiac tissue of newborns.
CONCLUSION
CONCLUSIONS
Our results also indicate, that dynamic and intricate balance among various elements in body may be affected by the lipid dietary supplements also in the pathological state. Utility of cardio-oncological approach in developmental programming study was confirmed.
Identifiants
pubmed: 34329902
pii: S0946-672X(21)00106-1
doi: 10.1016/j.jtemb.2021.126816
pii:
doi:
Substances chimiques
Linoleic Acids, Conjugated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126816Informations de copyright
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