Sex, drugs, and anaesthesia research.

Anesthesia Anesthetics / pharmacology Animals Female Male Pharmaceutical Preparations Rats
anaesthetic pharmacology electroencephalogram hypnotic neurosteroid sex difference

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
09 2021
Historique:
received: 09 04 2021
revised: 18 06 2021
accepted: 19 06 2021
pubmed: 1 8 2021
medline: 4 9 2021
entrez: 31 7 2021
Statut: ppublish

Résumé

In this issue of the British Journal of Anaesthesia, Joksimovic and colleagues report significant sex differences in sensitivity to the behavioural and neurophysiological effects of 3β-OH, a novel neurosteroid anesthetic. Female rats were more sensitive to the effects of 3β-OH than male rats, although the mechanims remain unclear. Sex differences have been understudied in anaesthesia research, and this article by Joksimovic and colleagues emphasizes the need to devote more effort to understanding these differences.

Identifiants

DOI: 10.1016/j.bja.2021.06.025 PMID: 34330415
pubmed: 34330415
pii: S0007-0912(21)00390-1
doi: 10.1016/j.bja.2021.06.025
pii:
doi:

Substances chimiques

Anesthetics 0
Pharmaceutical Preparations 0

Types de publication

Editorial Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

340-343

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM126155
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Auteurs

Olivia A Moody (OA)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.

Kathleen F Vincent (KF)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.

Ken Solt (K)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA. Electronic address: ksolt@mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Sex, drugs, and anaesthesia research.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Sex, drugs, and anaesthesia research.
questionsmedicales.fr › Eucaryotes › Animaux › Sex, drugs, and anaesthesia research.
questionsmedicales.fr › Préparations pharmaceutiques › Sex, drugs, and anaesthesia research.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Sex, drugs, and anaesthesia research.