Fine-tuning ALK1 linear polyubiquitination to control angiogenesis.

Activin Receptors, Type II / genetics Humans Neovascularization, Pathologic Signal Transduction Ubiquitination
ALK1 BMP9 LUBAC OTULIN angiogenesis arteriovenous malformation

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
09 2021
Historique:
received: 19 07 2021
revised: 19 07 2021
accepted: 19 07 2021
pubmed: 1 8 2021
medline: 15 12 2021
entrez: 31 7 2021
Statut: ppublish

Résumé

Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN is known to play a critical role in immune responses. A recent study by Fu et al. reveals how reversible linear polyubiquitination of the activin receptor-like kinase (ALK1) controls developmental angiogenesis and how its dysfunction leads to vascular malformations in humans.

Identifiants

DOI: 10.1016/j.tcb.2021.07.004 PMID: 34330579
pubmed: 34330579
pii: S0962-8924(21)00144-6
doi: 10.1016/j.tcb.2021.07.004
pii:
doi:

Substances chimiques

Activin Receptors, Type II EC 2.7.11.30

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

705-707

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Peter Ten Dijke (P)

Oncode Institute and Cell Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: P.ten_dijke@lumc.nl.

David Baker (D)

Oncode Institute and Cell Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs TGF-bêta › Récepteur activine › Récepteur activine, type 2 › Fine-tuning ALK1 linear polyubiquitination to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fine-tuning ALK1 linear polyubiquitination to...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Fine-tuning ALK1 linear polyubiquitination to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Fine-tuning ALK1 linear polyubiquitination to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Fine-tuning ALK1 linear polyubiquitination to...