Ligand-Independent G Protein-Coupled Estrogen Receptor/G Protein-Coupled Receptor 30 Activity: Lack of Receptor-Dependent Effects of G-1 and 17

Animals Arteries / drug effects Cell Line Cyclopentanes / pharmacology Disks Large Homolog 4 Protein / metabolism Estradiol / pharmacology Female Humans Ligands Mice Mice, Inbred C57BL Mice, Knockout Muscle Relaxation / drug effects PDZ Domains / genetics Quinolines / pharmacology Receptors, Estrogen / drug effects Receptors, G-Protein-Coupled / drug effects Saccharomyces cerevisiae / genetics

Journal

Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623

Informations de publication

Date de publication:
09 2021
Historique:
received: 22 02 2021
accepted: 06 06 2021
pubmed: 1 8 2021
medline: 9 11 2021
entrez: 31 7 2021
Statut: ppublish

Résumé

G protein-coupled receptor 30 (GPR30) is a membrane receptor reported to bind 17

Identifiants

DOI: 10.1124/molpharm.121.000259 PMID: 34330822 PMC: PMC8626787
pubmed: 34330822
pii: molpharm.121.000259
doi: 10.1124/molpharm.121.000259
pmc: PMC8626787
doi:

Substances chimiques

1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone 0
Cyclopentanes 0
Disks Large Homolog 4 Protein 0
GPER1 protein, human 0
GPER1 protein, mouse 0
Ligands 0
Quinolines 0
Receptors, Estrogen 0
Receptors, G-Protein-Coupled 0
Estradiol 4TI98Z838E

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

271-282

Informations de copyright

Copyright © 2021 by The Author(s).

Références

J Pharm Pharmacol. 2013 Oct;65(10):1488-99
pubmed: 24028616
Maturitas. 2014 Jun;78(2):123-30
pubmed: 24796498
Gene. 1995 Apr 14;156(1):119-22
pubmed: 7737504
Mol Cell Biol. 1996 Sep;16(9):4700-9
pubmed: 8756627
Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1055-61
pubmed: 20061543
Gen Comp Endocrinol. 2018 May 15;261:190-197
pubmed: 28450143
Mol Cell Biochem. 2012 Jul;366(1-2):239-49
pubmed: 22451019
Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):381-416
pubmed: 12382069
J Cardiovasc Pharmacol. 2011 May;57(5):598-603
pubmed: 21326105
J Mol Endocrinol. 2013 Jul 03;51(1):191-202
pubmed: 23674134
Steroids. 2010 Aug-Sep;75(8-9):603-10
pubmed: 20034504
J Mol Endocrinol. 2017 Aug;59(2):171-180
pubmed: 28733475
J Cell Sci. 2014 Jun 15;127(Pt 12):2749-60
pubmed: 24741069
Life Sci. 2017 Aug 15;183:21-27
pubmed: 28645860
Cancer Res. 2010 Feb 1;70(3):1184-94
pubmed: 20086172
PLoS One. 2020 Apr 17;15(4):e0231786
pubmed: 32302351
J Biol Chem. 2011 Jun 24;286(25):22441-55
pubmed: 21540189
Trends Endocrinol Metab. 2009 Oct;20(8):409-16
pubmed: 19734054
Mol Biol Cell. 2011 Dec;22(23):4647-56
pubmed: 21976697
Br J Pharmacol. 2011 Nov;164 Suppl 1:S1-324
pubmed: 22040146
J Biomol Screen. 2013 Jun;18(5):599-609
pubmed: 23396314
J Biol Chem. 2015 May 22;290(21):13293-307
pubmed: 25847233
Mol Endocrinol. 2010 Apr;24(4):709-21
pubmed: 20197310
J Cancer Res Clin Oncol. 2014 May;140(5):713-23
pubmed: 24553912
J Biol Chem. 2014 Aug 8;289(32):22117-27
pubmed: 24962572
Mol Pharmacol. 2011 Mar;79(3):400-10
pubmed: 21149639
BMC Cancer. 2012 Dec 28;12:624
pubmed: 23273253
J Biol Chem. 2005 Jun 24;280(25):23926-35
pubmed: 15805108
Breast Cancer Res Treat. 2014 May;145(1):61-71
pubmed: 24715381
J Biol Chem. 2007 May 25;282(21):15778-89
pubmed: 17369255
Nat Rev Mol Cell Biol. 2008 Jan;9(1):60-71
pubmed: 18043707
Pharmacol Rev. 2015 Jul;67(3):505-40
pubmed: 26023144
Anal Biochem. 2003 May 15;316(2):208-15
pubmed: 12711342
Endocrinology. 1999 Jul;140(7):2976-82
pubmed: 10385389
Endocrinology. 2011 Jun;152(6):2448-55
pubmed: 21427217
J Leukoc Biol. 2016 Feb;99(2):333-47
pubmed: 26394816
Nucleic Acids Res. 1996 Jul 1;24(13):2519-24
pubmed: 8692690
J Biol Chem. 2017 Jun 16;292(24):9932-9943
pubmed: 28450397
Clin Cancer Res. 2013 Apr 1;19(7):1681-92
pubmed: 23554355
Nature. 1992 Jun 25;357(6380):695-7
pubmed: 1377362
Horm Cancer. 2014 Jun;5(3):146-160
pubmed: 24718936
Endocrinology. 2002 Sep;143(9):3376-84
pubmed: 12193550
J Biol Chem. 2016 Apr 8;291(15):7788-95
pubmed: 26907689
Methods Enzymol. 2002;344:617-31
pubmed: 11771415
J Biol Chem. 1985 Nov 25;260(27):14428-30
pubmed: 3863818
FEBS Lett. 2003 Jul 3;546(1):65-72
pubmed: 12829238
J Mol Endocrinol. 2006 Feb;36(1):81-9
pubmed: 16461929
Nat Chem Biol. 2006 Apr;2(4):207-12
pubmed: 16520733
J Cell Sci. 2001 Sep;114(Pt 18):3219-31
pubmed: 11591811
Endocrinology. 2009 Apr;150(4):1563-5
pubmed: 19307418
Endocrinology. 2005 Feb;146(2):624-32
pubmed: 15539556
Endocrinology. 2009 Apr;150(4):1722-30
pubmed: 19095739
Nat Struct Mol Biol. 2018 Jan;25(1):4-12
pubmed: 29323277
Nature. 2009 May 21;459(7245):356-63
pubmed: 19458711
Mol Endocrinol. 2006 Sep;20(9):1996-2009
pubmed: 16645038
Endocrinology. 2009 Feb;150(2):687-98
pubmed: 18845638
J Recept Signal Transduct Res. 2017 Apr;37(2):181-188
pubmed: 27401115
Biosci Rep. 2019 Feb 26;39(2):
pubmed: 30760632
PLoS One. 2018 Jan 23;13(1):e0191418
pubmed: 29360846
Biochem Pharmacol. 2016 Aug 15;114:103-15
pubmed: 26920251
Circ Res. 2009 Feb 13;104(3):288-91
pubmed: 19179659
Steroids. 2014 Mar;81:99-102
pubmed: 24246735
J Neurosci. 2015 Feb 11;35(6):2384-97
pubmed: 25673833
Pharmacology. 2010;86(1):58-64
pubmed: 20639684
Endocrinology. 2007 Jul;148(7):3236-45
pubmed: 17379646
Endocrinology. 2008 Oct;149(10):4846-56
pubmed: 18566127
Vascul Pharmacol. 2002 Nov;39(4-5):187-99
pubmed: 12747959
Mol Endocrinol. 2009 Nov;23(11):1815-26
pubmed: 19749156
Sci Rep. 2017 May 2;7(1):1334
pubmed: 28465505
Mol Cell Endocrinol. 2014 May 25;389(1-2):71-83
pubmed: 24530924
Science. 2005 Mar 11;307(5715):1625-30
pubmed: 15705806
J Biol Chem. 2013 Mar 1;288(9):6438-50
pubmed: 23300088
Oncotarget. 2016 Aug 23;7(34):54983-54997
pubmed: 27448983

Auteurs

Julia Tutzauer (J)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

Ernesto Gonzalez de Valdivia (E)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

Karl Swärd (K)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

Ioannis Alexandrakis Eilard (I)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

Stefan Broselid (S)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

Robin Kahn (R)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

Björn Olde (B)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden.

L M Fredrik Leeb-Lundberg (LMF)

Department of Experimental Medical Science (J.T., E.G.d.V., K.S., I.A.E., S.B., L.M.F.L.-L.) and Department of Clinical Sciences Lund, Division of Pediatrics and Wallenberg Centre of Molecular Medicine (R.K.) and Division of Cardiology (B.O.), Lund University, Lund, Sweden fredrik.leeb-lundberg@med.lu.se.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclopentanes › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Homologue-4 de la protéine Disks Large › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Relâchement musculaire › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motifs et domaines d'intéraction protéique › Domaines PDZ › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Ligand-Independent G Protein-Coupled Estrogen...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Ligand-Independent G Protein-Coupled Estrogen...