A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.

Angiotensin-Converting Enzyme 2 / metabolism Animals Antibodies, Neutralizing / immunology Antibodies, Viral / immunology Binding Sites / immunology COVID-19 / immunology Cryoelectron Microscopy Crystallography, X-Ray Female Humans Mass Spectrometry / methods Mesocricetus Mice, Inbred C57BL Neutralization Tests Protein Binding / drug effects Receptors, Virus / metabolism SARS-CoV-2 / immunology Single-Domain Antibodies / chemistry

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
30 07 2021
Historique:
received: 10 09 2020
accepted: 15 07 2021
entrez: 31 7 2021
pubmed: 1 8 2021
medline: 17 8 2021
Statut: epublish

Résumé

SARS-CoV-2, the causative agent of COVID-19

Identifiants

DOI: 10.1038/s41467-021-24905-z PMID: 34330908 PMC: PMC8324831
pubmed: 34330908
doi: 10.1038/s41467-021-24905-z
pii: 10.1038/s41467-021-24905-z
pmc: PMC8324831
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Receptors, Virus 0
Single-Domain Antibodies 0
ACE2 protein, human EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4635

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2021. The Author(s).

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Auteurs

Tingting Li (T)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
ORCID: 0000-0003-3146-2761

Hongmin Cai (H)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
ORCID: 0000-0001-7221-8330

Hebang Yao (H)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
ORCID: 0000-0002-8588-5877

Bingjie Zhou (B)

University of CAS, Beijing, China.
CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.
ORCID: 0000-0002-7753-4065

Ning Zhang (N)

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China.

Martje Fentener van Vlissingen (MF)

Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, Netherlands.
European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.
ORCID: 0000-0003-2213-5910

Thijs Kuiken (T)

European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.
Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.
ORCID: 0000-0001-5501-9049

Wenyu Han (W)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
University of CAS, Beijing, China.

Corine H GeurtsvanKessel (CH)

European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.
Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.
ORCID: 0000-0002-7678-314X

Yuhuan Gong (Y)

University of CAS, Beijing, China.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China.

Yapei Zhao (Y)

University of CAS, Beijing, China.
CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.
ORCID: 0000-0001-7738-6181

Quan Shen (Q)

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China.

Wenming Qin (W)

National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), CAS, Shanghai, China.

Xiao-Xu Tian (XX)

National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), CAS, Shanghai, China.

Chao Peng (C)

National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), CAS, Shanghai, China.
ORCID: 0000-0002-6814-2676

Yanling Lai (Y)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
University of CAS, Beijing, China.

Yanxing Wang (Y)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.

Cedric A J Hutter (CAJ)

Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-8920-3343

Shu-Ming Kuo (SM)

CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.
ORCID: 0000-0002-4437-689X

Juan Bao (J)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.

Caixuan Liu (C)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
University of CAS, Beijing, China.

Yifan Wang (Y)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
University of CAS, Beijing, China.

Audrey S Richard (AS)

European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.
ORCID: 0000-0002-0207-0139

Hervé Raoul (H)

European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.
ORCID: 0000-0002-4241-3255

Jiaming Lan (J)

CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.

Markus A Seeger (MA)

Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0003-1761-8571

Yao Cong (Y)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
ORCID: 0000-0002-7164-8694

Barry Rockx (B)

European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.
Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.
ORCID: 0000-0003-2463-027X

Gary Wong (G)

CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China. garyckwong@ips.ac.cn.
Département de microbiologie-infectiologie et d'immunologie, Université Laval, Québec, QC, Canada. garyckwong@ips.ac.cn.
ORCID: 0000-0002-9044-8153

Yuhai Bi (Y)

University of CAS, Beijing, China. beeyh@im.ac.cn.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China. beeyh@im.ac.cn.
ORCID: 0000-0002-5595-363X

Dimitri Lavillette (D)

CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China. dlaville@ips.ac.cn.
Pasteurien College, Soochow University, Jiangsu, China. dlaville@ips.ac.cn.
ORCID: 0000-0002-4706-1519

Dianfan Li (D)

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China. dianfan.li@sibcb.ac.cn.
ORCID: 0000-0003-4729-4678

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Eucaryotes › Animaux › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Mesocricetus › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Tests de neutralisation › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › A synthetic nanobody targeting RBD protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fab d'immunoglobuline › Anticorps à domaine unique › A synthetic nanobody targeting RBD protects...