Antioxidant Activities and Selenogene Transcription in the European Sea Bass (Dicentrarchus labrax) Liver Depend, in a Non-linear Manner, on the Se/Hg Molar Ratio of the Feeds.
Dicentrarchus labrax
Fish
Glutathione peroxidase
Mercury (Hg)
Seafood
Selenium (Se)
Selenogene transcription
Thioredoxin reductase
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
02
01
2021
accepted:
09
07
2021
pubmed:
1
8
2021
medline:
26
4
2022
entrez:
31
7
2021
Statut:
ppublish
Résumé
Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively affected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the transcription of txn1, gpx1, and txnrd2. Feeding 6.7 mg Hg/kg for 53 days downregulated the genes of the thioredoxin system (txn1, txnrd3, and txnrd2) but upregulated gpx1, confirming the previously proposed complementarity among the antioxidant systems. Substitution of 20% of the feed by thawed white fish (hake) slightly counteracted the negative effects of Hg. The effects were not statistically significant and were dependent, in a non-linear manner, on the Se/Hg molar ratio of the feed but not on its Hg concentration. These results stress the need to consider the Se/Hg molar ratio of the feed/food when evaluating the toxicity of Hg.
Identifiants
pubmed: 34331176
doi: 10.1007/s12011-021-02835-7
pii: 10.1007/s12011-021-02835-7
pmc: PMC9023391
doi:
Substances chimiques
Antioxidants
0
Thioredoxins
52500-60-4
Mercury
FXS1BY2PGL
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2365-2379Subventions
Organisme : Spanish MINECO
ID : RTC-2014-2837-2
Organisme : Spanish MINECO
ID : CTM2012-40203-C02-01
Organisme : Euskampus Fundazioa-Campus of International Excellence
ID : 307615SAA2
Organisme : Eusko Jaurlaritza
ID : KK-2016/00057
Informations de copyright
© 2021. The Author(s).
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