Assigning evidence to actionability: An introduction to variant interpretation in precision cancer medicine.

molecular biomarker molecular tumor board precision oncology variant classification

Journal

Genes, chromosomes & cancer
ISSN: 1098-2264
Titre abrégé: Genes Chromosomes Cancer
Pays: United States
ID NLM: 9007329

Informations de publication

Date de publication:
06 2022
Historique:
received: 22 05 2021
accepted: 25 07 2021
pubmed: 1 8 2021
medline: 20 5 2022
entrez: 31 7 2021
Statut: ppublish

Résumé

Modern concepts in precision cancer medicine are based on increasingly complex genomic analyses and require standardized criteria for the functional evaluation and reporting of detected genomic alterations in order to assess their clinical relevance. In this article, we propose and address the necessary steps in systematic variant evaluation consisting of bioinformatic analysis, functional annotation and clinical interpretation, focusing on the latter two aspects. We discuss the role and clinical application of current variant classification systems and point out their scope and limitations. Finally, we highlight the significance of the molecular tumor board as a platform for clinical decision-making based on genomic analyses.

Identifiants

pubmed: 34331337
doi: 10.1002/gcc.22987
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

303-313

Informations de copyright

© 2021 The Authors. Genes, Chromosomes and Cancer published by Wiley Periodicals LLC.

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Auteurs

Peter Horak (P)

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Center for Personalized Medicine (ZPM), Heidelberg, Germany.

Jonas Leichsenring (J)

Institut für Pathologie, Zytologie und molekulare Diagnostik, Regiomed Klinikum Coburg, Coburg, Germany.
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Hannah Goldschmid (H)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Simon Kreutzfeldt (S)

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.

Daniel Kazdal (D)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
German Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.

Veronica Teleanu (V)

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Volker Endris (V)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Laura Gieldon (L)

Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.

Michael Allgäuer (M)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Anna-Lena Volckmar (AL)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Nicola Dikow (N)

Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.

Marcus Renner (M)

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.

Martina Kirchner (M)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Roland Penzel (R)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Carolin Ploeger (C)

Center for Personalized Medicine (ZPM), Heidelberg, Germany.
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Regine Brandt (R)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Huriye Seker-Cin (H)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Jan Budczies (J)

German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
German Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.

Christoph E Heilig (CE)

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.

Olaf Neumann (O)

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Christian P Schaaf (CP)

Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.

Peter Schirmacher (P)

German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Center for Personalized Medicine (ZPM), Heidelberg, Germany.
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Stefan Fröhling (S)

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Center for Personalized Medicine (ZPM), Heidelberg, Germany.

Albrecht Stenzinger (A)

German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Center for Personalized Medicine (ZPM), Heidelberg, Germany.
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
German Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.

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