Protective Effects of Curcumin on Endothelium: An Updated Review.

Antioxidants Cardiovascular Diseases / drug therapy Curcumin / pharmacology Endothelium, Vascular Humans Nitric Oxide
Adhesion molecule Arterial dysfunction Atherosclerosis Curcumin Curcuminoid Endothelial dysfunction Endothelium FMD Nitric oxide bioavailability

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2021
Historique:
entrez: 31 7 2021
pubmed: 1 8 2021
medline: 4 8 2021
Statut: ppublish

Résumé

Endothelial dysfunction is the common early stage of most cardiovascular afflictions. The endothelium is considered the main mediator of vascular homeostasis via its vasodilator, anti-inflammatory and anticoagulant properties. Among the different endothelial-derived mediators, nitric oxide is produced by nitric oxide synthase and has a critical role in regulating endothelial function. Physiological and pathological processes such as aging and diabetes mellitus are associated with disturbances of endothelial function which, at least at the earliest stage, can be reversed by lifestyle and pharmacological intervention to reduce the risk of incident cardiovascular diseases. Among dietary strategies, curcumin is a cheap and safe nutraceutical polyphenol with proven antioxidant and anti-inflammatory properties. Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized. This review summarizes the available literature on the beneficial role of curcumin on vascular endothelial function.

Identifiants

DOI: 10.1007/978-3-030-56153-6_6 PMID: 34331686
pubmed: 34331686
doi: 10.1007/978-3-030-56153-6_6
doi:

Substances chimiques

Antioxidants 0
Nitric Oxide 31C4KY9ESH
Curcumin IT942ZTH98

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103-119

Informations de copyright

© 2021. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Mona Alidadi (M)

School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Luca Liberale (L)

Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.

Fabrizio Montecucco (F)

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, Genoa, Italy.
First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

Muhammed Majeed (M)

Sabinsa Corporation, East Windsor, NJ, USA.

Khalid Al-Rasadi (K)

Medical Research Centre, Sultan Qaboos University, Muscat, Oman.

Maciej Banach (M)

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland.
Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.

Tannaz Jamialahmadi (T)

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Amirhossein Sahebkar (A)

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
Halal Research Center of IRI, FDA, Tehran, Iran. sahebkara@mums.ac.ir.
Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. sahebkara@mums.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Protective Effects of Curcumin on Endothelium:...
questionsmedicales.fr › Maladies cardiovasculaires › Protective Effects of Curcumin on Endothelium:...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Protective Effects of Curcumin on Endothelium:...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Protective Effects of Curcumin on Endothelium:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protective Effects of Curcumin on Endothelium:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Protective Effects of Curcumin on Endothelium:...