Benzodiazepine high-doses: The need for an accurate definition.
anxiolytics
benzodiazepine
high-dose use
hypnotics
long-term use
Journal
International journal of methods in psychiatric research
ISSN: 1557-0657
Titre abrégé: Int J Methods Psychiatr Res
Pays: United States
ID NLM: 9111433
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
02
07
2021
received:
25
02
2021
accepted:
14
07
2021
pubmed:
1
8
2021
medline:
15
12
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
A clear definition of what we understand of high-dose misuse or of a 'markedly increased dose' (as stated by the DSM-5) is important and past definitions may be inadequate. The aim of this review is to describe the different definitions used and to test these definitions for their accuracy. A narrative PubMed literature review was conducted based on articles published between 1 January 1990 and 31 December 2020 describing benzodiazepines (in MeSH Terms or MeSH Major Topic) and high-dose (or high-dosage). Specific definitions were applied to a population sample to show how definitions affect high-dose benzodiazepine prevalence. Multiples of an equivalent-diazepam dose or of the World Health Organization 'defined daily dosage' were used more frequently than the overstep of the recommended maximum therapeutic dosage as a cut-off point. High-dose use is rare but the prevalence in the general population varies among studies, mainly due to different definitions, making both clinical and epidemiological comparisons between studies difficult. Defining a high-dose user as a person who takes at least a higher dose than the maximum usual therapeutic dose over a defined period of time therefore appears to be clinically more consistent.
Identifiants
pubmed: 34331787
doi: 10.1002/mpr.1888
pmc: PMC8633930
doi:
Substances chimiques
Benzodiazepines
12794-10-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1888Informations de copyright
© 2021 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.
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