T cells protect against hepatitis A virus infection and limit infection-induced liver injury.

Analysis of Variance Animals Disease Models, Animal Hepatitis A / drug therapy Hepatitis A virus / drug effects Liver Diseases / drug therapy Mice North Carolina Statistics, Nonparametric T-Lymphocytes / metabolism
Hepatitis A Virus T cell vaccine T cells liver infection liver pathogenesis mice type-1 interferons

Journal

Journal of hepatology
ISSN: 1600-0641
Titre abrégé: J Hepatol
Pays: Netherlands
ID NLM: 8503886

Informations de publication

Date de publication:
12 2021
Historique:
received: 05 02 2021
revised: 07 07 2021
accepted: 19 07 2021
pubmed: 1 8 2021
medline: 9 2 2022
entrez: 31 7 2021
Statut: ppublish

Résumé

Hepatitis A virus (HAV) is a common cause of enterically transmitted viral hepatitis. In non-immune individuals, infection results in typically transient but occasionally fulminant and fatal inflammatory liver injury. Virus-specific T cell frequencies peak when liver damage is at its zenith, leading to the prevalent notion that T cells exacerbate liver disease, as suspected for other hepatotropic virus infections. However, the overall contribution of T cells to the control of HAV and the pathogenesis of hepatitis A is unclear and has been impeded by a historic lack of small animal models. Ifnar1 A large population of virus-specific T cells accumulated within the livers of Ifnar1 These data show that T cells protect against HAV-mediated liver injury and can be targeted to improve liver health. Hepatitis A virus is a leading cause of acute viral hepatitis worldwide. T cells were thought to contribute to liver injury during acute infection. We now show that virus-specific T cells protect against infection and limit liver injury.

Sections du résumé

BACKGROUND & AIMS
Hepatitis A virus (HAV) is a common cause of enterically transmitted viral hepatitis. In non-immune individuals, infection results in typically transient but occasionally fulminant and fatal inflammatory liver injury. Virus-specific T cell frequencies peak when liver damage is at its zenith, leading to the prevalent notion that T cells exacerbate liver disease, as suspected for other hepatotropic virus infections. However, the overall contribution of T cells to the control of HAV and the pathogenesis of hepatitis A is unclear and has been impeded by a historic lack of small animal models.
METHODS
Ifnar1
RESULTS
A large population of virus-specific T cells accumulated within the livers of Ifnar1
CONCLUSION
These data show that T cells protect against HAV-mediated liver injury and can be targeted to improve liver health.
LAY SUMMARY
Hepatitis A virus is a leading cause of acute viral hepatitis worldwide. T cells were thought to contribute to liver injury during acute infection. We now show that virus-specific T cells protect against infection and limit liver injury.

Identifiants

DOI: 10.1016/j.jhep.2021.07.019 PMID: 34331968 PMC: PMC8604763
pubmed: 34331968
pii: S0168-8278(21)01949-8
doi: 10.1016/j.jhep.2021.07.019
pmc: PMC8604763
mid: NIHMS1730073
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1323-1334

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI143894
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI103083
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI138337
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131685
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150095
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare no competing financial interests. Please refer to the accompanying ICMJE disclosure forms for further details.

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Auteurs

Ichiro Misumi (I)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: imisumi@email.unc.edu.

Joseph E Mitchell (JE)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Makayla M Lund (MM)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

John M Cullen (JM)

Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA.

Stanley M Lemon (SM)

Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Jason K Whitmire (JK)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jwhitmir@email.unc.edu.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de variance › T cells protect against hepatitis A virus...
questionsmedicales.fr › Eucaryotes › Animaux › T cells protect against hepatitis A virus...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › T cells protect against hepatitis A virus...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Hépatite › Hépatites virales humaines › Hépatite A › T cells protect against hepatitis A virus...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Picornaviridae › Hepatovirus › Virus de l'hépatite A › T cells protect against hepatitis A virus...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › T cells protect against hepatitis A virus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › T cells protect against hepatitis A virus...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › États du Sud-Est des États-Unis › Caroline du Nord › T cells protect against hepatitis A virus...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Statistique non paramétrique › T cells protect against hepatitis A virus...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › T cells protect against hepatitis A virus...