Spontaneous otoacoustic emissions are biomarkers for mice with tectorial membrane defects.
Ceacam16
Cochlea
Otoancorin
Spontaneous otoacoustic emissions
Tecta
Tectorial membrane
Journal
Hearing research
ISSN: 1878-5891
Titre abrégé: Hear Res
Pays: Netherlands
ID NLM: 7900445
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
28
01
2021
revised:
22
06
2021
accepted:
12
07
2021
pubmed:
1
8
2021
medline:
5
2
2022
entrez:
31
7
2021
Statut:
ppublish
Résumé
Cochlear function depends on the operation of a coupled feedback loop, incorporating outer hair cells (OHCs), and structured to assure that inner hair cells (IHCs) convey frequency specific acoustic information to the brain, even at very low sound levels. Although our knowledge of OHC function and its contribution to cochlear amplification has expanded, the importance of the tectorial membrane (TM) to the processing of mechanical inputs has not been fully elucidated. In addition, there are a surprising number of genetic mutations that affect TM structure and that produce hearing loss in humans. By synthesizing old and new results obtained on several mouse mutants, we learned that animals with abnormal TMs are prone to generate spontaneous otoacoustic emissions (SOAE), which are uncommon in most wildtype laboratory animals. Because SOAEs are not produced in TM mutants or in humans when threshold shifts exceed approximately 25 dB, some degree of cochlear amplification is required. However, amplification by itself is not sufficient because normal mice are rarely spontaneous emitters. Since SOAEs reflect active cochlear operation, TM mutants are valuable for studying the oscillatory nature of the amplification process and the structures associated with its stabilization. Inasmuch as the mouse models were selected to mirror human auditory disorders, using SOAEs as a noninvasive clinical tool may assist the classification of individuals with genetic defects that influence the active mechanisms responsible for sensitivity and frequency selectivity, the hallmarks of mammalian hearing.
Identifiants
pubmed: 34332206
pii: S0378-5955(21)00148-9
doi: 10.1016/j.heares.2021.108314
pmc: PMC8419146
mid: NIHMS1730490
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108314Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC000089
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The author declares no conflict of interest.
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