Collective behaviours in organoids.
Cell competition
Cell migration
Collective behaviors
Mechanics
Organoids
Oscillation
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
30
04
2021
revised:
18
06
2021
accepted:
25
06
2021
pubmed:
1
8
2021
medline:
26
11
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
Collective behaviour emerges from interacting units within communities, such as migrating herds, swimming fish schools, and cells within tissues. At the microscopic level, collective behaviours include collective cell migration in development and cancer invasion, rhythmic gene expression in pattern formation, cell competition in homeostasis and cancer, force generation and mechano-sensing in morphogenesis. Studying the initiation and the maintenance of collective cell behaviours is key to understand the principles of development, regeneration and disease. However, the manifold influences of contributing factors in in vivo environments challenge the dissection of causalities in animal models. As an alternative model that has emerged to overcome this difficulty, in vitro three-dimensional organoid cultures provide a reductionist approach yet retain similarities with the in vivo tissue in cellular composition and tissue organisation. Here, we focus on recent progresses in studying collective behaviours in different organoid systems and discuss their advantages and the possibility of improvement for future applications.
Identifiants
pubmed: 34332339
pii: S0955-0674(21)00075-2
doi: 10.1016/j.ceb.2021.06.006
pmc: PMC8533486
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-90Subventions
Organisme : European Research Council
ID : 758617
Pays : International
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement No conflict of interest.
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