A clinical-in silico study on the effectiveness of multipoint bicathodic and cathodic-anodal pacing in cardiac resynchronization therapy.
Bidomain model
Cardiac electromechanical simulations
Cardiac resynchronization therapy
Cathodic-anodal pacing
Multipoint pacing
Journal
Computers in biology and medicine
ISSN: 1879-0534
Titre abrégé: Comput Biol Med
Pays: United States
ID NLM: 1250250
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
07
04
2021
revised:
16
07
2021
accepted:
16
07
2021
pubmed:
1
8
2021
medline:
9
10
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
Up to one-third of patients undergoing cardiac resynchronization therapy (CRT) are nonresponders. Multipoint bicathodic and cathodic-anodal left ventricle (LV) stimulations could overcome this clinical challenge, but their effectiveness remains controversial. Here we evaluate the performance of such stimulations through both in vivo and in silico experiments, the latter based on computer electromechanical modeling. Seven patients, all candidates for CRT, received a quadripolar LV lead. Four stimulations were tested: right ventricular (RVS); conventional single point biventricular (S-BS); multipoint biventricular bicathodic (CC-BS) and multipoint biventricular cathodic-anodal (CA-BS). The following parameters were processed: QRS duration; maximal time derivative of arterial pressure (dPdt
Identifiants
pubmed: 34332350
pii: S0010-4825(21)00455-8
doi: 10.1016/j.compbiomed.2021.104661
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104661Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.