A positron emission tomography study of the serotonin1B receptor effect of electroconvulsive therapy for severe major depressive episodes.
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
received:
12
05
2021
revised:
09
07
2021
accepted:
12
07
2021
pubmed:
1
8
2021
medline:
30
10
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
Electroconvulsive therapy (ECT) is an effective treatment for depressive disorders, although its molecular mechanism of action is unknown. The serotonin 1B (5-HT The objective of this longitudinal PET study was to examine the effect of ECT for depression on 5-HT Thirteen patients completed the study according to protocol. Eleven out of thirteen patients responded to ECT. 5-HT Albeit representative of a PET study, the sample size is still small and there are potential confounding effects of medication. Increased 5-HT
Sections du résumé
BACKGROUND
Electroconvulsive therapy (ECT) is an effective treatment for depressive disorders, although its molecular mechanism of action is unknown. The serotonin 1B (5-HT
METHODS
The objective of this longitudinal PET study was to examine the effect of ECT for depression on 5-HT
RESULTS
Thirteen patients completed the study according to protocol. Eleven out of thirteen patients responded to ECT. 5-HT
LIMITATIONS
Albeit representative of a PET study, the sample size is still small and there are potential confounding effects of medication.
CONCLUSIONS
Increased 5-HT
Identifiants
pubmed: 34332365
pii: S0165-0327(21)00739-4
doi: 10.1016/j.jad.2021.07.060
pii:
doi:
Substances chimiques
Ketamine
690G0D6V8H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
645-651Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.