Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue.
Aged
Anti-Bacterial Agents
/ pharmacokinetics
Cancellous Bone
/ metabolism
Cefuroxime
/ pharmacokinetics
Cohort Studies
Female
Hallux Rigidus
/ surgery
Hallux Valgus
/ surgery
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Muscle, Skeletal
/ metabolism
Orthopedic Procedures
/ methods
Subcutaneous Fat
/ metabolism
Time Factors
Tourniquets
Journal
Acta orthopaedica
ISSN: 1745-3682
Titre abrégé: Acta Orthop
Pays: Sweden
ID NLM: 101231512
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
3
8
2021
medline:
15
12
2021
entrez:
2
8
2021
Statut:
ppublish
Résumé
Background and purpose - Tourniquet is widely used in orthopedic surgery to reduce intraoperative bleeding and improve visualization. We evaluated the effect of tourniquet application on peri- and postoperative cefuroxime concentrations in subcutaneous tissue, skeletal muscle, calcaneal cancellous bone, and plasma. The primary endpoint was the time for which the free cefuroxime concentration was maintained above the clinical breakpoint minimal inhibitory concentration (T > MIC) for
Identifiants
pubmed: 34334093
doi: 10.1080/17453674.2021.1942620
pmc: PMC8635659
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cefuroxime
O1R9FJ93ED
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
746-752Références
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