Preparation of Fine-Drugs Layered Spherical Particles with Good Micromeritic and Dissolution Properties through Ultra Cryo-Milling and Mechanical Powder Processing.

Anticonvulsants / chemistry Chemistry, Pharmaceutical Drug Compounding Particle Size Phenytoin / chemistry Powders Solubility
dry composite mixing liquid nitrogen mechanical powder processing micromeritics ordered mixture ultra cryo-milling

Journal

Chemical & pharmaceutical bulletin
ISSN: 1347-5223
Titre abrégé: Chem Pharm Bull (Tokyo)
Pays: Japan
ID NLM: 0377775

Informations de publication

Date de publication:
2021
Historique:
entrez: 2 8 2021
pubmed: 3 8 2021
medline: 18 9 2021
Statut: ppublish

Résumé

The particles of phenytoin (Phe), a poorly water-soluble model drug, were bead-milled alone or co-milled with a hydrophilic waxy additive using an ultra cryo-milling technique in liquid nitrogen (LN

Identifiants

DOI: 10.1248/cpb.c21-00182 PMID: 34334518
pubmed: 34334518
doi: 10.1248/cpb.c21-00182
doi:

Substances chimiques

Anticonvulsants 0
Powders 0
Phenytoin 6158TKW0C5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

747-759

Auteurs

Daiki Tsuboi (D)

Department of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.

Keita Kondo (K)

Department of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.

Toshiyuki Niwa (T)

Department of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Anticonvulsivants › Preparation of Fine-Drugs Layered Spherical...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › Preparation of Fine-Drugs Layered Spherical...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Preparation of Fine-Drugs Layered Spherical...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Preparation of Fine-Drugs Layered Spherical...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolidines › Hydantoïnes › Phénytoïne › Preparation of Fine-Drugs Layered Spherical...
questionsmedicales.fr › Préparations pharmaceutiques › Poudres › Preparation of Fine-Drugs Layered Spherical...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Preparation of Fine-Drugs Layered Spherical...