Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease.
Journal
Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652
Informations de publication
Date de publication:
02 Aug 2021
02 Aug 2021
Historique:
received:
10
09
2020
accepted:
20
04
2021
revised:
23
03
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Bone-produced fibroblast growth factor 23 (FGF23) increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2; LCN2 the murine homolog) is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression. We investigated bone FGF23 regulation by circulating LCN2. At 23 weeks, Col4a3
Identifiants
pubmed: 34334787
doi: 10.1038/s41413-021-00154-0
pii: 10.1038/s41413-021-00154-0
pmc: PMC8326281
doi:
Types de publication
Journal Article
Langues
eng
Pagination
35Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK101730
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102815
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114158
Pays : United States
Informations de copyright
© 2021. The Author(s).
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