A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis
bisphosphonate
hidden hearing loss
inner ear
neurotrophin-3
regeneration
sensorineural hearing loss
small molecule
synaptopathy
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
02
2021
accepted:
18
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival, neurite outgrowth, and synaptogenesis could lead to significant gains for hearing-impaired patients. There has therefore been intense interest in the use of neurotrophic factors in the inner ear to promote both survival of SGNs and re-wiring of sensory hair cells by surviving SGNs. Neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) represent the primary neurotrophins in the inner ear during development and throughout adulthood, and have demonstrated potential for SGN survival and neurite outgrowth. We have pioneered a hybrid molecule approach to maximize SGN stimulation
Identifiants
pubmed: 34335184
doi: 10.3389/fncel.2021.666706
pmc: PMC8319950
doi:
Types de publication
Journal Article
Langues
eng
Pagination
666706Informations de copyright
Copyright © 2021 Kempfle, Duro, Zhang, Amador, Kuang, Lu, Kashemirov, Edge, McKenna and Jung.
Déclaration de conflit d'intérêts
DJ receives compensation and stock options as a consultant for Akouos. Akouos is a participant in the Department of Defense Grant listed under Funding, but was not involved in this study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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