Hepatitis E Virus Persistence and/or Replication in the Peripheral Blood Mononuclear Cells of Acute HEV-Infected Patients.
HEV
PBMCs
acute hepatitis
cytokines
gene expression
persistence and replication
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
04
2021
accepted:
11
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Hepatitis E virus (HEV) causes about 14 million infections with 300,000 deaths and 5,200 stillbirths worldwide annually. Extrahepatic manifestations are reported with HEV infections, such as renal, neurological, and hematological disorders. Recently, we reported that stool-derived HEV-1 replicates efficiently in human monocytes and macrophages PBMCs were isolated from AHE patients ( HEV RNA was detected in the PBMCs of AHE patients. The median HEV load in the PBMCs was 1.34 × 10 Our study shows evidence for
Sections du résumé
BACKGROUND
BACKGROUND
Hepatitis E virus (HEV) causes about 14 million infections with 300,000 deaths and 5,200 stillbirths worldwide annually. Extrahepatic manifestations are reported with HEV infections, such as renal, neurological, and hematological disorders. Recently, we reported that stool-derived HEV-1 replicates efficiently in human monocytes and macrophages
METHODS
METHODS
PBMCs were isolated from AHE patients (
RESULTS
RESULTS
HEV RNA was detected in the PBMCs of AHE patients. The median HEV load in the PBMCs was 1.34 × 10
CONCLUSION
CONCLUSIONS
Our study shows evidence for
Identifiants
pubmed: 34335528
doi: 10.3389/fmicb.2021.696680
pmc: PMC8322848
doi:
Types de publication
Journal Article
Langues
eng
Pagination
696680Informations de copyright
Copyright © 2021 Sayed, Abd Elhameed, Abd El-Kareem, Abdel-Malek, Ali, Ibrahim, Sayed, Khalaf, Abdel-Wahid and El-Mokhtar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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