Prebiotic Supplementation During Pregnancy Modifies the Gut Microbiota and Increases Metabolites in Amniotic Fluid, Driving a Tolerogenic Environment
Acetates
/ metabolism
Amniotic Fluid
/ metabolism
Animals
B-Lymphocyte Subsets
/ immunology
Butyrates
/ metabolism
Dendritic Cells
/ immunology
Dietary Supplements
Feces
/ chemistry
Female
Fetus
/ immunology
Gastrointestinal Microbiome
Humans
Immune Tolerance
Inulin
/ administration & dosage
Maternal-Fetal Exchange
Mice
Mice, Inbred BALB C
Oligosaccharides
/ administration & dosage
Placenta
/ cytology
Prebiotics
Pregnancy
Pregnancy Outcome
Pregnancy, Animal
/ immunology
Prenatal Exposure Delayed Effects
Propionates
/ metabolism
Ribotyping
T-Lymphocyte Subsets
/ immunology
Uterus
/ cytology
feto-maternal tissues
gut microbiota
immune imprinting
immune tolerance
prebiotic
pregnancy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
05
2021
accepted:
30
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
21
12
2021
Statut:
epublish
Résumé
The gut microbiota is influenced by environmental factors such as food. Maternal diet during pregnancy modifies the gut microbiota composition and function, leading to the production of specific compounds that are transferred to the fetus and enhance the ontogeny and maturation of the immune system. Prebiotics are fermented by gut bacteria, leading to the release of short-chain fatty acids that can specifically interact with the immune system, inducing a switch toward tolerogenic populations and therefore conferring health benefits. In this study, pregnant BALB/cJRj mice were fed either a control diet or a diet enriched in prebiotics (Galacto-oligosaccharides/Inulin). We hypothesized that galacto-oligosaccharides/inulin supplementation during gestation could modify the maternal microbiota, favoring healthy immune imprinting in the fetus. Galacto-oligosaccharides/inulin supplementation during gestation increases the abundance of
Identifiants
pubmed: 34335628
doi: 10.3389/fimmu.2021.712614
pmc: PMC8317504
doi:
Substances chimiques
Acetates
0
Butyrates
0
Oligosaccharides
0
Prebiotics
0
Propionates
0
Inulin
9005-80-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
712614Informations de copyright
Copyright © 2021 Brosseau, Selle, Duval, Misme-Aucouturier, Chesneau, Brouard, Cherbuy, Cariou, Bouchaud, Mincham, Strickland, Barbarot and Bodinier.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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