Identification of Genomic Regions Influencing N-Metabolism and N-Excretion in Lactating Holstein- Friesians.
GWAS
cattle
emission
milk urea
nitrogen
non-urea nitrogen
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
04
2021
accepted:
18
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Excreted nitrogen (N) of dairy cows contribute to environmental eutrophication. The main N-excretory metabolite of dairy cows is urea, which is synthesized as a result of N-metabolization in the liver and is excreted via milk and urine. Genetic variation in milk urea (MU) has been postulated but the complex physiology behind the trait as well as the tremendous diversity of processes regulating the N-metabolism impede the consistent determination of causal regions in the bovine genome. In order to map the genetic determinants affecting N-excretion, MU and eight other N-excretory metabolites in milk and urine were assessed in a genome-wide association study. Therefore phenotypes of 371 Holstein- Friesians were obtained in a trial on a dairy farm under near commercial conditions. Genotype data comprised SNP information of the Bovine 50K MD Genome chip (45,613 SNPs). Significantly associated genomic regions for MU concentration revealed
Identifiants
pubmed: 34335696
doi: 10.3389/fgene.2021.699550
pmc: PMC8318802
doi:
Types de publication
Journal Article
Langues
eng
Pagination
699550Informations de copyright
Copyright © 2021 Honerlagen, Reyer, Oster, Ponsuksili, Trakooljul, Kuhla, Reinsch and Wimmers.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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