Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases.
clinicopathology
gastric inflammatory myofibroblastic tumor
Journal
Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
10
09
2019
accepted:
08
01
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
ppublish
Résumé
The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast-fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diverse morphological structure, were observed. In the mucous vascular structure, mucoid or collagenous areas, fibromatosis- or scar-like lesions were generally <10 mm in size and both had diffuse or patchy plasma cells, lymphocytes and other inflammatory-cell infiltration backgrounds. The immunophenotype was vimentin- and smooth muscle actin-positive with pan-cytokeratin, desmin and calponin expression and CD34-positive foci; furthermore, three cases were positive for anaplastic lymphoma kinase expression. Gastric IMT is rare, with unique histopathological changes and corrosion-like invasion of the smooth muscle of the stomach wall, blood vessels, nerves and adipose tissue. It should be differentiated from a variety of spindle cell tumor types and tumor-like lesions.
Identifiants
pubmed: 34335890
doi: 10.3892/etm.2021.10380
pii: ETM-0-0-10380
pmc: PMC8290396
doi:
Types de publication
Journal Article
Langues
eng
Pagination
948Informations de copyright
Copyright: © Wang et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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