A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy.
Journal
Case reports in oncological medicine
ISSN: 2090-6706
Titre abrégé: Case Rep Oncol Med
Pays: United States
ID NLM: 101581035
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
04
2021
accepted:
18
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
We report a case of a 25-year-old pregnant woman diagnosed with a large, unresectable retroperitoneal synovial sarcoma. Successful neoadjuvant treatment with doxorubicin plus ifosfamide prepartum and continuing postpartum resulted in significant disease response allowing for later tumor resection. Following the first prepartum chemotherapy cycle, a decreased amniotic fluid index was noted, representing a potential complication of chemotherapy. Induction of labor was performed at 33 weeks gestation with excellent outcome in the newborn. This case highlights the complex medical decision-making process in the setting of cancer diagnosed during pregnancy, balancing oncologic and obstetric concerns, and to our knowledge is only the second reported case of synovial sarcoma treated with neoadjuvant cytotoxic chemotherapy in the antepartum period.
Identifiants
pubmed: 34336322
doi: 10.1155/2021/9982171
pmc: PMC8313357
doi:
Types de publication
Case Reports
Langues
eng
Pagination
9982171Informations de copyright
Copyright © 2021 Bradley H. Sipe et al.
Déclaration de conflit d'intérêts
All authors declare no competing interests related to this report.
Références
Eur Urol. 2006 Jul;50(1):148-50
pubmed: 16519992
Ann Diagn Pathol. 2014 Dec;18(6):369-80
pubmed: 25438927
Curr Oncol Rep. 2020 Feb 5;22(2):17
pubmed: 32025953
Tumori. 2007 Jan-Feb;93(1):45-52
pubmed: 17455871
N Engl J Med. 2015 Nov 5;373(19):1824-34
pubmed: 26415085
BMJ Case Rep. 2019 Jan 29;12(1):
pubmed: 30700464
Am J Clin Oncol. 2010 Jun;33(3):221-8
pubmed: 19745695
J Clin Diagn Res. 2017 Jul;11(7):PD13-PD14
pubmed: 28892972
Bol Asoc Med P R. 2012 Jul-Sep;104(3):55-6
pubmed: 23156894
Indian J Surg. 2013 Jun;75(Suppl 1):463-4
pubmed: 24426649
Case Rep Oncol. 2014 Feb 26;7(1):139-43
pubmed: 24707262
Jpn J Thorac Cardiovasc Surg. 2006 May;54(5):217-20
pubmed: 16764312
Obstet Gynecol. 2008 Feb;111(2 Pt 2):555-8
pubmed: 18239021
J Obstet Gynaecol India. 2014 Dec;64(Suppl 1):22-3
pubmed: 25404798
J Clin Oncol. 2010 Feb 1;28(4):683-9
pubmed: 19841323
Eur Urol. 2006 Aug;50(2):375-6
pubmed: 18217223
Rom J Morphol Embryol. 2015;56(1):289-94
pubmed: 25826519
Best Pract Res Clin Obstet Gynaecol. 2016 May;33:2-18
pubmed: 26542928
Cancer. 2004 Aug 1;101(3):627-34
pubmed: 15274077
J Clin Oncol. 2005 Jun 20;23(18):4192-7
pubmed: 15961766
Ther Adv Med Oncol. 2017 Jun;9(6):415-429
pubmed: 28607580
Cancer Chemother Pharmacol. 2012 Feb;69(2):357-67
pubmed: 21769666