The Second Oncogenic Hit Determines the Cell Fate of
B-cell
childhood leukemia
germline
mouse models
somatic
transcription factors
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
05
2021
accepted:
18
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
ETV6-RUNX1 is almost exclusively associated with childhood B-cell acute lymphoblastic leukemia (B-ALL), but the consequences of ETV6-RUNX1 expression on cell lineage decisions during B-cell leukemogenesis are completely unknown. Clinically silent ETV6-RUNX1 preleukemic clones are frequently found in neonatal cord blood, but few carriers develop B-ALL as a result of secondary genetic alterations. The understanding of the mechanisms underlying the first transforming steps could greatly advance the development of non-toxic prophylactic interventions. Using genetic lineage tracing, we examined the capacity of ETV6-RUNX1 to instruct a malignant phenotype in the hematopoietic lineage by cell-specific Cre-mediated activation of ETV6-RUNX1 from the endogenous
Identifiants
pubmed: 34336858
doi: 10.3389/fcell.2021.704591
pmc: PMC8320889
doi:
Types de publication
Journal Article
Langues
eng
Pagination
704591Informations de copyright
Copyright © 2021 Rodríguez-Hernández, Casado-García, Isidro-Hernández, Picard, Raboso-Gallego, Alemán-Arteaga, Orfao, Blanco, Riesco, Prieto-Matos, García Criado, García Cenador, Hock, Enver, Sanchez-Garcia and Vicente-Dueñas.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Genet. 2014 Feb;46(2):116-25
pubmed: 24413735
Nat Rev Immunol. 2021 Feb 8;:
pubmed: 33558682
Nat Rev Cancer. 2018 Aug;18(8):471-484
pubmed: 29784935
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8242-7
pubmed: 12048236
Nature. 2018 Mar 15;555(7696):371-376
pubmed: 29489755
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
Bioinformatics. 2010 Aug 15;26(16):2069-70
pubmed: 20562413
Genome Biol. 2011;12(1):R1
pubmed: 21205303
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Science. 2008 Jan 18;319(5861):336-9
pubmed: 18202291
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Blood. 2020 Oct 29;136(18):2003-2017
pubmed: 32911536
Cancer Genet Cytogenet. 2001 Oct 15;130(2):93-104
pubmed: 11675129
Blood. 2018 Feb 15;131(7):821-826
pubmed: 29311095
Trends Immunol. 2021 May;42(5):371-374
pubmed: 33773925
Nat Immunol. 2015 Jul;16(7):766-774
pubmed: 25985233
Leukemia. 2015 Apr;29(4):839-46
pubmed: 25388957
Nat Commun. 2019 Dec 5;10(1):5563
pubmed: 31804490
Nature. 2007 Sep 27;449(7161):473-7
pubmed: 17851532
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
Cancer Res. 2017 Aug 15;77(16):4365-4377
pubmed: 28630052
Cell. 2011 Apr 1;145(1):25-9
pubmed: 21458665
J Exp Med. 2011 Jun 6;208(6):1135-49
pubmed: 21606506
Nat Genet. 2017 Aug;49(8):1211-1218
pubmed: 28671688
Cancer Discov. 2015 Dec;5(12):1328-43
pubmed: 26408659
Cell Stem Cell. 2009 Jul 2;5(1):43-53
pubmed: 19570513
Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):174-80
pubmed: 25696852
Cancer Res. 2018 May 15;78(10):2669-2679
pubmed: 29490943
Oncotarget. 2017 Sep 27;8(60):102674-102680
pubmed: 29254279
Dev Cell. 2018 Feb 5;44(3):362-377.e7
pubmed: 29290585
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):255-60
pubmed: 24367082
Nat Rev Clin Oncol. 2019 Apr;16(4):227-240
pubmed: 30546053
Trends Cancer. 2018 Jun;4(6):408-417
pubmed: 29860985
Nat Methods. 2010 Apr;7(4):248-9
pubmed: 20354512
Cell. 1994 Dec 2;79(5):901-12
pubmed: 8001127
J Pharmacol Pharmacother. 2010 Jul;1(2):94-9
pubmed: 21350617
Neoplasia. 2013 Nov;15(11):1292-300
pubmed: 24339741
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94
pubmed: 16940357
Nat Protoc. 2009;4(7):1073-81
pubmed: 19561590