Persistency of Mesenchymal Stromal/Stem Cells in Lungs.
BLI
BM-MSCs
MSCs
MSCs tracking
lung
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
05
2021
accepted:
17
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Mesenchymal stromal/stem cells (MSCs) are a fibroblast-like cell population with high regenerative potential that can be isolated from many different tissues. Several data suggest MSCs as a therapeutic tool capable of migrating to a site of injury and guide tissue regeneration mainly through their secretome. Pulmonary first-pass effect occurs during intravenous administration of MSCs, where 50 to 80% of the cells tend to localize in the lungs. This phenomenon has been exploited to study MSC potential therapeutic effects in several preclinical models of lung diseases. Data demonstrated that, regardless of the lung disease severity and the delivery route, MSCs were not able to survive longer than 24 h in the respiratory tract but still surprisingly determined a therapeutic effect. In this work, two different mouse bone marrow-derived mesenchymal stromal/stem cell (mBM-MSC) lines, stably transduced with a third-generation lentiviral vector expressing luciferase and green fluorescent protein reporter genes tracking MSCs
Identifiants
pubmed: 34336863
doi: 10.3389/fcell.2021.709225
pmc: PMC8322774
doi:
Types de publication
Journal Article
Langues
eng
Pagination
709225Informations de copyright
Copyright © 2021 Ferrini, Stellari, Franceschi, Macchi, Russo, Murgia, Grisendi, Villetti, Dominici and Donofrio.
Déclaration de conflit d'intérêts
EF, GV, and FS were employed by company Chiesi Farmaceutici S.p.A. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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