Chronic Kidney Allograft Disease: New Concepts and Opportunities.
graft survival
kidney disease
regeneration
review
transplantation
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
01
2021
accepted:
10
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is increasing in most countries and kidney transplantation is the best option for those patients requiring renal replacement therapy. Therefore, there is a significant number of patients living with a functioning kidney allograft. However, progressive kidney allograft functional deterioration remains unchanged despite of major advances in the field. After the first post-transplant year, it has been estimated that this chronic allograft damage may cause a 5% graft loss per year. Most studies focused on mechanisms of kidney graft damage, especially on ischemia-reperfusion injury, alloimmunity, nephrotoxicity, infection and disease recurrence. Thus, therapeutic interventions focus on those modifiable factors associated with chronic kidney allograft disease (CKaD). There are strategies to reduce ischemia-reperfusion injury, to improve the immunologic risk stratification and monitoring, to reduce calcineurin-inhibitor exposure and to identify recurrence of primary renal disease early. On the other hand, control of risk factors for chronic disease progression are particularly relevant as kidney transplantation is inherently associated with renal mass reduction. However, despite progress in pathophysiology and interventions, clinical advances in terms of long-term kidney allograft survival have been subtle. New approaches are needed and probably a holistic view can help. Chronic kidney allograft deterioration is probably the consequence of damage from various etiologies but can be attenuated by kidney repair mechanisms. Thus, besides immunological and other mechanisms of damage, the intrinsic repair kidney graft capacity should be considered to generate new hypothesis and potential therapeutic targets. In this review, the critical risk factors that define CKaD will be discussed but also how the renal mechanisms of regeneration could contribute to a change chronic kidney allograft disease paradigm.
Identifiants
pubmed: 34336878
doi: 10.3389/fmed.2021.660334
pmc: PMC8316649
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
660334Informations de copyright
Copyright © 2021 Codina, Manonelles, Tormo, Sola and Cruzado.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Am Soc Nephrol. 2015 Aug;26(8):1961-74
pubmed: 25568173
Kidney Int. 2021 Mar;99(3):671-685
pubmed: 32889013
Transplantation. 2007 Apr 27;83(8):1027-34
pubmed: 17452891
Transplantation. 2016 Feb;100(2):391-9
pubmed: 26555944
J Am Soc Nephrol. 2011 Jul;22(7):1262-74
pubmed: 21719782
N Engl J Med. 2007 Dec 20;357(25):2562-75
pubmed: 18094377
J Nephrol. 2021 Apr;34(2):531-538
pubmed: 32533451
Am J Transplant. 2007 Mar;7(3):560-70
pubmed: 17229079
Transplant Proc. 2019 May;51(4):1096-1100
pubmed: 31101179
Kidney Int. 2015 Feb;87(2):272-5
pubmed: 25635719
Nephrol Dial Transplant. 2009 Mar;24(3):1039-47
pubmed: 19103734
Am J Transplant. 2010 Mar;10(3):464-71
pubmed: 20121738
Transplantation. 2000 Sep 27;70(6):887-95
pubmed: 11014642
J Am Soc Nephrol. 2006 Mar;17(3):889-99
pubmed: 16481415
Nat Commun. 2018 Apr 9;9(1):1344
pubmed: 29632300
Transplantation. 2017 Apr;101(4):713-726
pubmed: 27941433
Transplantation. 2013 Apr 27;95(8):1008-14
pubmed: 23591726
Clin Transplant. 2018 Mar;32(3):e13194
pubmed: 29315820
N Engl J Med. 2002 Jul 11;347(2):103-9
pubmed: 12110738
Am J Transplant. 2018 Feb;18(2):293-307
pubmed: 29243394
Kidney Int. 2002 May;61(5):1880-6
pubmed: 11967040
Nat Immunol. 2013 Oct;14(10):986-95
pubmed: 24048120
N Engl J Med. 2019 Jan 24;380(4):347-357
pubmed: 30415602
N Engl J Med. 2016 Jul 28;375(4):323-34
pubmed: 27299675
Am J Transplant. 2003 Feb;3(2):186-91
pubmed: 12614296
Transpl Int. 2007 Nov;20(11):962-9
pubmed: 17666021
Nat Rev Nephrol. 2011 Nov 15;8(1):34-42
pubmed: 22083141
J Am Soc Nephrol. 2018 Jan;29(1):260-267
pubmed: 29038286
Transplantation. 1996 Oct 15;62(7):920-6
pubmed: 8878385
Transplantation. 2019 Jul;103(7):1477-1485
pubmed: 30747850
Am J Transplant. 2018 Dec;18(12):2955-2964
pubmed: 29637714
J Am Soc Nephrol. 2005 Jul;16(7):2225-33
pubmed: 15888559
Clin J Am Soc Nephrol. 2017 Aug 7;12(8):1321-1336
pubmed: 28576905
Am J Transplant. 2012 Feb;12(2):388-99
pubmed: 22081892
Transplantation. 2011 Mar 27;91(6):666-71
pubmed: 21317839
Transpl Infect Dis. 2018 Apr;20(2):e12828
pubmed: 29272071
Am J Kidney Dis. 2011 Jul;58(1):118-26
pubmed: 21684438
Pediatr Nephrol. 1997 Feb;11(1):108-20
pubmed: 9035184
Clin J Am Soc Nephrol. 2020 Feb 7;15(2):247-256
pubmed: 31974287
BMC Nephrol. 2014 Nov 06;15:174
pubmed: 25376243
J Am Soc Nephrol. 2006 Sep;17(9):2443-56
pubmed: 16885410
Nephrology (Carlton). 2016 Aug;21(8):647-54
pubmed: 26780694
J Res Pharm Pract. 2018 Apr-Jun;7(2):69-76
pubmed: 30050959
Am J Transplant. 2021 Feb 9;:
pubmed: 33565206
F1000Prime Rep. 2014 Mar 03;6:13
pubmed: 24669294
Blood. 2009 Mar 19;113(12):2851-8
pubmed: 18997170
Nephrol Dial Transplant. 2018 Sep 1;33(9):1661-1668
pubmed: 29635410
Nat Rev Nephrol. 2017 Jan;13(1):39-46
pubmed: 27890924
J Immunol. 2015 Dec 15;195(12):5525-31
pubmed: 26637661
J Am Soc Nephrol. 2018 Jul;29(7):1979-1991
pubmed: 29752413
Am J Transplant. 2019 Oct;19(10):2876-2888
pubmed: 30887675
Transplantation. 2011 Feb 15;91(3):334-41
pubmed: 21242885
Clin J Am Soc Nephrol. 2010 May;5(5):790-7
pubmed: 20185599
Nephrol Dial Transplant. 2012 Jun;27(6):2553-8
pubmed: 22167589
Transplant Proc. 2015 Mar;47(2):394-8
pubmed: 25769580
PLoS Genet. 2018 Oct 12;14(10):e1007698
pubmed: 30312291
Diabetes Care. 2019 Jun;42(6):1067-1074
pubmed: 30862658
Transplantation. 2003 Jan 15;75(1):66-71
pubmed: 12544873
Transplantation. 1999 May 15;67(9):1222-30
pubmed: 10342313
J Am Soc Nephrol. 2012 Apr;23(4):739-49
pubmed: 22343119
Transplantation. 2015 Dec 30;100(12):2710-2716
pubmed: 26720301
Clin Transplant. 2019 Apr;33(4):e13516
pubmed: 30849194
Nephrol Dial Transplant. 2008 Oct;23(10):3138-45
pubmed: 18458033
Am J Transplant. 2009 May;9(5):1081-6
pubmed: 19344432
Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1435-43
pubmed: 26071493
Front Immunol. 2020 Aug 06;11:1204
pubmed: 32849490
Am J Kidney Dis. 2015 Mar;65(3):484-9
pubmed: 25530108
J Transl Med. 2018 Mar 7;16(1):52
pubmed: 29514693
Nephrol Dial Transplant. 2013 Jun;28(6):1362-70
pubmed: 23348884
Nat Commun. 2018 Feb 21;9(1):754
pubmed: 29467410
Trends Mol Med. 2019 May;25(5):366-381
pubmed: 30935780
Kidney Int. 2006 Feb;69(4):655-62
pubmed: 16395271
Kidney Int. 2003 Jun;63(6):2286-94
pubmed: 12753320
Am J Transplant. 2009 Dec;9 Suppl 4:S267-72
pubmed: 20070689
Kidney Int. 2017 Feb;91(2):304-314
pubmed: 27837947
Am J Transplant. 2005 Aug;5(8):1997-2004
pubmed: 15996251
Kidney Int. 2015 Feb;87(2):343-9
pubmed: 25229341
Nat Rev Nephrol. 2012 Nov;8(11):643-57
pubmed: 23026949
Am J Transplant. 2008 Mar;8(3):492-6
pubmed: 18294145
Transpl Int. 2008 Jun;21(6):523-30
pubmed: 18266773
Am J Transplant. 2011 Mar;11(3):450-62
pubmed: 20973913
Transplantation. 2012 Mar 27;93(6):624-31
pubmed: 22334041
PLoS One. 2018 Jun 21;13(6):e0199445
pubmed: 29928026
N Engl J Med. 2003 Dec 11;349(24):2326-33
pubmed: 14668458
Transpl Int. 2009 Nov;22(11):1073-80
pubmed: 19624495
Am J Transplant. 2012 Apr;12(4):1029-38
pubmed: 22233329
N Engl J Med. 2019 Jun 13;380(24):2295-2306
pubmed: 30990260
Transplantation. 2008 Apr 15;85(7 Suppl):S3-9
pubmed: 18401260
N Engl J Med. 1999 Dec 2;341(23):1725-30
pubmed: 10580071
Am J Transplant. 2005 May;5(5):1130-6
pubmed: 15816896
Kidney Int. 2010 Apr;77(8):721-8
pubmed: 20130531
Am J Transplant. 2007 Jun;7(6):1506-14
pubmed: 17359512
Trials. 2015 Jun 23;16:282
pubmed: 26099226
N Engl J Med. 2007 Dec 20;357(25):2601-14
pubmed: 18094380
J Am Soc Nephrol. 2016 Sep;27(9):2762-70
pubmed: 26940093
Transplantation. 2006 Mar 15;81(5):704-10
pubmed: 16534472
Lancet. 2017 May 27;389(10084):2152-2162
pubmed: 28561006
Physiology (Bethesda). 2015 May;30(3):183-94
pubmed: 25933819
Am J Transplant. 2018 Apr;18(4):927-935
pubmed: 28949089
Blood. 2007 Oct 1;110(7):2235-41
pubmed: 17554059
Transplantation. 2004 May 15;77(9):1457-9
pubmed: 15167607
Transpl Infect Dis. 2020 Aug;22(4):e13300
pubmed: 32323406
Transplant Proc. 2005 Nov;37(9):3705-9
pubmed: 16386512
J Am Soc Nephrol. 2020 Sep;31(9):2193-2204
pubmed: 32764139
PLoS One. 2017 Jun 13;12(6):e0178801
pubmed: 28609473
Curr Opin Organ Transplant. 2011 Dec;16(6):594-9
pubmed: 21971511
Transplant Direct. 2018 Aug 21;4(9):e384
pubmed: 30234153
N Engl J Med. 2018 Sep 20;379(12):1150-1160
pubmed: 30231232
Diabetes Metab Res Rev. 2017 Nov;33(8):
pubmed: 28731619
Stem Cell Reports. 2015 Aug 11;5(2):248-63
pubmed: 26235895
Am J Transplant. 2011 Apr;11(4):698-707
pubmed: 21062418
Nephrol Dial Transplant. 2005 Apr;20(4):699-706
pubmed: 15716294
Transplantation. 2002 Mar 15;73(5):775-82
pubmed: 11907427
J Immunol Res. 2014;2014:159479
pubmed: 24868561
Transplantation. 2015 Aug;99(8):1709-14
pubmed: 25675198
Am J Kidney Dis. 2003 Jun;41(6):1314-21
pubmed: 12776285
Transplant Proc. 2020 Jan - Feb;52(1):175-178
pubmed: 31924404
Eur J Clin Invest. 2011 Sep;41(9):971-8
pubmed: 21382021
Transplantation. 2006 Jan 15;81(1):117-20
pubmed: 16421486
Am J Transplant. 2017 Sep;17(9):2381-2389
pubmed: 28199785
N Engl J Med. 2013 Sep 26;369(13):1215-26
pubmed: 24066742
Clin J Am Soc Nephrol. 2011 Jul;6(7):1609-16
pubmed: 21700823
Transplantation. 2003 May 15;75(9):1490-5
pubmed: 12792502
Cochrane Database Syst Rev. 2019 Mar 15;3:CD011671
pubmed: 30875082
Clin Transplant. 2019 Sep;33(9):e13528
pubmed: 30859620
Transplantation. 2016 Oct;100(10):2219-21
pubmed: 27136263
Am J Transplant. 2015 Nov;15(11):2921-30
pubmed: 26096305
N Engl J Med. 1991 Oct 10;325(15):1058-62
pubmed: 1891007
Clin J Am Soc Nephrol. 2009 Feb;4(2):481-508
pubmed: 19218475
Am J Transplant. 2008 Aug;8(8):1719-28
pubmed: 18694475
BMC Nephrol. 2018 Sep 12;19(1):229
pubmed: 30208881
Am J Transplant. 2011 Jul;11(7):1456-63
pubmed: 21672152
Transplantation. 1996 Jun 15;61(11):1576-81
pubmed: 8669100
N Engl J Med. 1984 Sep 13;311(11):699-705
pubmed: 6382005
J Clin Invest. 2008 Nov;118(11):3522-30
pubmed: 18982158
Am J Transplant. 2019 Oct;19(10):2855-2864
pubmed: 31017369
Am J Kidney Dis. 2004 Aug;44(2):353-62
pubmed: 15264195
Transplantation. 2007 Jul 27;84(2):137-43
pubmed: 17667803
J Am Soc Nephrol. 2003 Jul;14(7):1880-8
pubmed: 12819249
Kidney Int. 2015 Oct;88(4):851-8
pubmed: 26108067
BMJ Open. 2019 Oct 7;9(10):e031812
pubmed: 31594897
J Am Soc Nephrol. 2012 Apr;23(4):629-40
pubmed: 22282596
Lancet Diabetes Endocrinol. 2016 Apr;4(4):318-26
pubmed: 26608067
Am J Transplant. 2011 Aug;11(8):1645-9
pubmed: 21797974
Am J Transplant. 2016 Dec;16(12):3468-3478
pubmed: 27184779
Clin Kidney J. 2016 Dec;9(6):765-771
pubmed: 27994852
N Engl J Med. 2005 Feb 10;352(6):558-69
pubmed: 15703421
BMC Med. 2015 May 12;13:111
pubmed: 25963131
Circ Heart Fail. 2016 Oct;9(10):
pubmed: 27729391
Am J Transplant. 2016 Jan;16(1):194-203
pubmed: 26274817
BMC Nephrol. 2018 Sep 15;19(1):232
pubmed: 30219043
Am J Transplant. 2010 Sep;10(9):2017-25
pubmed: 20883535
Nephrol Dial Transplant. 2013 May;28(5):1305-14
pubmed: 23229925
Nephrol Dial Transplant. 2012 Jan;27(1):417-22
pubmed: 21622985
Am J Transplant. 2009 Nov;9 Suppl 3:S1-155
pubmed: 19845597
Kidney Blood Press Res. 2019;44(5):984-992
pubmed: 31437852
Transplantation. 2020 Sep;104(9):1832-1841
pubmed: 31978000
J Nephrol. 2012 Mar-Apr;25(2):245-54
pubmed: 21725919
Front Physiol. 2018 Oct 10;9:1412
pubmed: 30364198
Anesthesiology. 2014 Nov;121(5):1099-121
pubmed: 25211170
J Am Soc Nephrol. 2011 Feb;22(2):317-26
pubmed: 21289217
Lancet. 2013 Jul 20;382(9888):260-72
pubmed: 23727169
Transpl Int. 2016 Feb;29(2):241-52
pubmed: 26563524
Am J Transplant. 2019 Apr;19(4):984-994
pubmed: 30506632
Am J Transplant. 2002 Nov;2(10):970-4
pubmed: 12482151
Nephrol Dial Transplant. 2019 Jul 1;34(7):1240-1250
pubmed: 30476254
Kidney Int. 2006 Sep;70(6):1019-25
pubmed: 16837925
Open Forum Infect Dis. 2019 May 21;6(6):ofz243
pubmed: 31214630
Indian J Nephrol. 2019 Jul-Aug;29(4):278-281
pubmed: 31423063
Clin Infect Dis. 2005 Aug 1;41(3):354-60
pubmed: 16007533
Kidney Int. 2007 Aug;72(3):290-9
pubmed: 17440493
Am J Transplant. 2015 May;15(5):1293-302
pubmed: 25731800
Transpl Int. 2019 Aug;32(8):775-788
pubmed: 30955215
Am J Transplant. 2011 Nov;11(11):2405-13
pubmed: 21942930
Sci Transl Med. 2011 Jun 1;3(85):85ra46
pubmed: 21632984
J Am Soc Nephrol. 2017 Jul;28(7):2053-2067
pubmed: 28209809
J Am Soc Nephrol. 2018 Feb;29(2):591-605
pubmed: 29242250
Nephrol Dial Transplant. 2003 May;18(5):1013-4
pubmed: 12686681
Am J Kidney Dis. 2015 Jan;65(1):80-7
pubmed: 25446024