Refining the rat sciatic nerve block: a novel ultrasound-guided technique.
alternatives
anaesthesia
analgesia
pain reduction
refinement
Journal
Laboratory animals
ISSN: 1758-1117
Titre abrégé: Lab Anim
Pays: England
ID NLM: 0112725
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
pubmed:
3
8
2021
medline:
10
5
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
Murine translational models are an important tool to understand pain pathophysiology. One procedure used frequently in murine research is the sciatic nerve block. This study sought to demonstrate the use of ultrasound-guided sciatic nerve block in a cadaveric murine model. A total of 40 injections were performed in 20 Sprague-Dawley male 18-month-old rat cadavers. Necropsy was performed to identify staining of the sciatic nerve. Staining with methylene blue occurred in 40 of 40 ultrasound-guided injections. The extremely accurate nature of this block under ultrasound guidance is favorable for future translational studies in rats undergoing sciatic nerve blocks. This method may represent a significant improvement in current methods.
Identifiants
pubmed: 34338061
doi: 10.1177/00236772211034627
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM