Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.

Alzheimer Disease Atherosclerosis / epidemiology Blood Proteins Cognitive Dysfunction / epidemiology Dementia / epidemiology Humans Prospective Studies tau Proteins
cognitive decline cohort study dementia longitudinal study proteomics

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
04 2022
Historique:
revised: 21 05 2021
received: 18 03 2021
accepted: 09 06 2021
pubmed: 3 8 2021
medline: 9 4 2022
entrez: 2 8 2021
Statut: ppublish

Résumé

Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20-year follow-ups. In the Whitehall II prospective cohort study proteins were measured using SOMAscan technology. Cognitive performance was tested five times over 20 years. Linkage to electronic health records identified incident dementia. The results were replicated in the Atherosclerosis Risk in Communities (ARIC) study. Fifteen non-amyloid/non-tau-related proteins were associated with cognitive decline and dementia, were consistently identified in both cohorts, and were not explained by known dementia risk factors. Levels of six of the proteins are modifiable by currently approved medications for other conditions. This study identified several plasma proteins in dementia-free people that are associated with long-term risk of cognitive decline and dementia.

Identifiants

DOI: 10.1002/alz.12419 PMID: 34338426 PMC: PMC9292245
pubmed: 34338426
doi: 10.1002/alz.12419
pmc: PMC9292245
doi:

Substances chimiques

Blood Proteins 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

612-624

Subventions

Organisme : British Heart Foundation
ID : RG/16/11/32334
Pays : United Kingdom
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : Wellcome Trust
ID : 221854/Z/20/Z
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004402
Pays : United States
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/2/30098
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG056477
Pays : United States
Organisme : Medical Research Council
ID : MR/S011676/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL087641
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056477
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG064122
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG062553
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : K24 AG052573
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States

Informations de copyright

© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Joni V Lindbohm (JV)

Department of Epidemiology and Public Health, University College London, London, UK.
Department of Public Health Clinicum, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-9820-2692

Nina Mars (N)

Institute for Molecular Medicine Finland (FIMM) HiLIFE, University of Helsinki, Helsinki, Finland.

Keenan A Walker (KA)

Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.

Archana Singh-Manoux (A)

Department of Epidemiology and Public Health, University College London, London, UK.
Epidemiology of Ageing and Neurodegenerative diseases, Université de Paris, Paris, France.

Gill Livingston (G)

Division of Psychiatry, University College London, London, UK.
Camden and Islington Foundation Trust, London, UK.

Eric J Brunner (EJ)

Department of Epidemiology and Public Health, University College London, London, UK.

Pyry N Sipilä (PN)

Department of Public Health Clinicum, University of Helsinki, Helsinki, Finland.

Kalle Saksela (K)

Department of Virology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland.

Jane E Ferrie (JE)

Department of Epidemiology and Public Health, University College London, London, UK.
Bristol Medical School (PHS), University of Bristol, Bristol, UK.

Ruth C Lovering (RC)

Functional Gene Annotation, Institute of Cardiovascular Science, University College London, London, UK.

Stephen A Williams (SA)

SomaLogic, Inc., Boulder, Colorado, USA.

Aroon D Hingorani (AD)

Institute of Cardiovascular Science, University College London, London, UK.
British Heart Foundation Research Accelerator, University College London, London, UK.
Health Data Research, London, UK.

Rebecca F Gottesman (RF)

Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, USA.

Henrik Zetterberg (H)

Department of Neurodegenerative Disease and UK Dementia Research Institute, University College London, London, UK.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Mika Kivimäki (M)

Department of Epidemiology and Public Health, University College London, London, UK.
Department of Public Health Clinicum, University of Helsinki, Helsinki, Finland.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Plasma proteins, cognitive decline, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Plasma proteins, cognitive decline, and...