The development of
Angiotensin-Converting Enzyme 2
/ metabolism
Animals
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
COVID-19
/ immunology
HEK293 Cells
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Molecular
Pandemics
Protein Binding
Protein Conformation
Receptors, Virus
/ immunology
SARS-CoV-2
/ drug effects
Single-Domain Antibodies
/ chemistry
Spike Glycoprotein, Coronavirus
/ metabolism
COVID-19 Drug Treatment
ACE2
COVID-19
animal model
crystal structures
drug pharmacokinetics
infectious disease
microbiology
single-chain antibody from camelids
spike protein receptor-binding domain
virus
virus neutralization
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 08 2021
02 08 2021
Historique:
received:
11
11
2020
accepted:
28
07
2021
pubmed:
3
8
2021
medline:
18
8
2021
entrez:
2
8
2021
Statut:
epublish
Résumé
Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a series of single-domain antibodies (i.e., nanobody),
Identifiants
pubmed: 34338634
doi: 10.7554/eLife.64815
pii: 64815
pmc: PMC8354634
doi:
pii:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Receptors, Virus
0
Single-Domain Antibodies
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI089728
Pays : United States
Organisme : NIH HHS
ID : R01AI157975
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI157975
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIH HHS
ID : R35GM118047
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118047
Pays : United States
Organisme : NIH HHS
ID : R01AI089728
Pays : United States
Organisme : NIH HHS
ID : S10 OD021527
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2021, Ye et al.
Déclaration de conflit d'intérêts
GY, JG, JS, YW, AL, FL The University of Minnesota has filed a patent on Nanosota-1 drugs with F.L, G.Y., A.M.L., J.P.G., J.S., and Y.W. as inventors. JZ, CM, KS, WT, AO, MV, LD, HA, SP No competing interests declared
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