Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function.
RNA-binding proteins
SR proteins
SRSF1
alternative splicing
biochemistry
chemical biology
chromosomes
gene expression
mRNA translation
motile cilia
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 08 2021
02 08 2021
Historique:
received:
23
11
2020
accepted:
30
07
2021
pubmed:
3
8
2021
medline:
9
10
2021
entrez:
2
8
2021
Statut:
epublish
Résumé
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. The SR family proteins regulate RNA splicing in the nucleus and a subset of them, including SRSF1, shuttles between the nucleus and cytoplasm affecting post-splicing processes. However, the physiological significance of this remains unclear. Here, we used genome editing to knock-in a nuclear retention signal (NRS) in
Identifiants
pubmed: 34338635
doi: 10.7554/eLife.65104
pii: 65104
pmc: PMC8352595
doi:
pii:
Substances chimiques
Srsf1 protein, mouse
0
Serine-Arginine Splicing Factors
170974-22-8
Banques de données
GEO
['GSE157269', 'GSE161828']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 208402/Z/17
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/7
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/14
Pays : United Kingdom
Informations de copyright
© 2021, Haward et al.
Déclaration de conflit d'intérêts
FH, MM, PY, NB, JH, SA, JL, Av, DW, PM, IA, JC No competing interests declared
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