The life in a gradient: calcium, the lncRNA SPRR2C and mir542/mir196a meet in the epidermis to regulate the aging process.
epidermal barrier
lncRNA
miRNA
pseudogene
skin aging
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
02 08 2021
02 08 2021
Historique:
received:
05
08
2020
accepted:
17
07
2021
pubmed:
3
8
2021
medline:
12
1
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
The turnover of the epidermis beginning with the progenitor cells in the basal layer to the fully differentiated corneocytes is tightly regulated by calcium. Calcium more than anything else promotes the differentiation of keratinocytes which implies the need for a calcium gradient with low concentrations in the stratum basale and high concentrations in the stratum granulosum. One of the hallmarks of skin aging is a collapse of this gradient that has a direct impact on the epidermal fitness. The rise of calcium in the stratum basale reduces cell proliferation, whereas the drop of calcium in the stratum granulosum leads to a changed composition of the cornified envelope. We showed that keratinocytes respond to the calcium induced block of cell division by a large increase of the expression of several miRNAs (hsa-mir542-5p, hsa-mir125a, hsa-mir135a-5p, hsa-mir196a-5p, hsa-mir491-5p and hsa-mir552-5p). The pitfall of this rescue mechanism is a dramatic change in gene expression which causes a further impairment of the epidermal barrier. This effect is attenuated by a pseudogene (SPRR2C) that gives rise to a lncRNA. SPRR2C specifically resides in the stratum granulosum/corneum thus acting as a sponge for miRNAs.
Identifiants
pubmed: 34339392
pii: 203385
doi: 10.18632/aging.203385
pmc: PMC8386546
doi:
Substances chimiques
Cornified Envelope Proline-Rich Proteins
0
MIRN196 microRNA, human
0
MIRN542 microRNA, human
0
MicroRNAs
0
RNA, Long Noncoding
0
SPRR2C protein, human
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19127-19144Références
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