Associations between respiratory and vascular function in early childhood.
early life
maternal education
particulate matter
respiratory function
smoking
vascular function
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
12
05
2021
received:
04
02
2021
accepted:
01
07
2021
pubmed:
3
8
2021
medline:
5
1
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
The link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity. We determined if an association exists between respiratory and cardiovascular function in young children and, if so, whether it is confounded by known cardiorespiratory risk factors. Respiratory and vascular data from a prospective cohort study established to evaluate the health implications 3 years after coal mine fire smoke exposure in children aged 3-5 years were used. Respiratory function was measured using the forced oscillation technique and included resistance at 5 Hz (R Peripheral lung function (X These observations suggest that peripheral lung stiffness is associated with vascular stiffness and that this relationship is established early in life.
Sections du résumé
BACKGROUND AND OBJECTIVE
The link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity. We determined if an association exists between respiratory and cardiovascular function in young children and, if so, whether it is confounded by known cardiorespiratory risk factors.
METHODS
Respiratory and vascular data from a prospective cohort study established to evaluate the health implications 3 years after coal mine fire smoke exposure in children aged 3-5 years were used. Respiratory function was measured using the forced oscillation technique and included resistance at 5 Hz (R
RESULTS
Peripheral lung function (X
CONCLUSION
These observations suggest that peripheral lung stiffness is associated with vascular stiffness and that this relationship is established early in life.
Substances chimiques
Particulate Matter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1060-1066Informations de copyright
© 2021 Asian Pacific Society of Respirology.
Références
Elstad M, O'Callaghan EL, Smith AJ, Ben-Tal A, Ramchandra R. Cardiorespiratory interactions in humans and animals: rhythms for life. Am J Physiol. 2018;315:H6-H17.
Hsia CC, Hyde DM, Weibel ER. Lung structure and the intrinsic challenges of gas exchange. Compr Physiol. 2016;6:827-95.
Hole DJ, Watt GC, Davey-Smith G, Hart CL, Gillis CR, Hawthorne VM. Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study. BMJ. 1996;313:711-6.
McAllister DA, Newby DE. Association between impaired lung function and cardiovascular disease. Cause, effect, or force of circumstance? Am J Respir Crit Care Med. 2016;194:3-5.
Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest. 2005;127:1952-9.
Chandra D, Gupta A, Strollo PJ Jr, Fuhrman CR, Leader JK, Bon J, et al. Airflow limitation and endothelial dysfunction. Unrelated and independent predictors of atherosclerosis. Am J Respir Crit Care Med. 2016;194:38-47.
Lange P, Nyboe J, Appleyard M, Jensen G, Schnohr P. Spirometric findings and mortality in never-smokers. J Clin Epidemiol. 1990;43:867-73.
Ingebrigtsen TS, Marott JL, Vestbo J, Nordestgaard BG, Lange P. Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap. BMJ Open Respir Res. 2020;7:e000470.
Ayer JG, Belousova EG, Harmer JA, Toelle B, Celermajer DS, Marks GB. Lung function is associated with arterial stiffness in children. PLoS One. 2011;6:e26303.
Bolton CE, Stocks J, Hennessy E, Cockcroft JR, Fawke J, Lum S, et al. The EPICure study: association between hemodynamics and lung function at 11 years after extremely preterm birth. J Pediatr. 2012;161:595-601.
Eising JB, van der Ent CK, Evelein AMV, Uiterwaal CSPM. The association between lung function and arterial stiffness in young childhood. Eur Respir J. 2014;44:530-2.
McEvoy CT, Spindel ER. Pulmonary effects of maternal smoking on the fetus and child: effects on lung development, respiratory morbidities, and life long lung health. Paediatr Respir Rev. 2017;21:27-33.
Banderali G, Martelli A, Landi M, Moretti F, Betti F, Radaelli G, et al. Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review. J Transl Med. 2015;13:327-34.
Spencer N. Maternal education, lone parenthood, material hardship, maternal smoking, and longstanding respiratory problems in childhood: testing a hierarchical conceptual framework. J Epidemiol Community Health. 2005;59:842-6.
Geelhoed JJ, El Marroun H, Verburg BO, van Osch-Gevers L, Hofman A, Huizink AC, et al. Maternal smoking during pregnancy, fetal arterial resistance adaptations and cardiovascular function in childhood. BJOG. 2011;118:755-62.
Lewis KM, Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, et al. Mother's education and offspring asthma risk in 10 European cohort studies. Eur J Epidemiol. 2017;32:797-805.
Zhao B, Johnston FH, O'Sullivan T, Williamson GJ, Melody S, Dalton M, et al. Early life exposure to coal mine fire and tobacco smoke affect subclinical vascular function. Arch Dis Child. 2019;105:539-44.
Shao J, Zosky GR, Hall GL, Wheeler AJ, Dharmage S, Melody S, et al. Early life exposure to coal mine fire smoke emissions and altered lung function in young children. Respirology. 2020;25:198-205.
Melody SM, Wheeler AJ, Dalton M, Williamson GJ, Negishi K, Willis G, et al. Cohort profile: the Hazelwood Health Study Latrobe Early Life Follow-Up (ELF) study. Int J Epidemiol. 2020;49:1779-80.
Beydon N, Davis SD, Lombardi E, Allen JL, Arets HG, Aurora P, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med. 2007;175:1304-45.
Calogero C, Simpson SJ, Lombardi E, Parri N, Cuomo B, Palumbo M, et al. Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years. Pediatr Pulmonol. 2013;48:707-15.
Lorenz M, Markus H, Bots M, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness. Circulation. 2007;115:459-67.
Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588-605.
Luhar AK, Emmerson KM, Reisen F, Williamson GJ, Cope ME. Modelling smoke distribution in the vicinity of a large and prolonged fire from an open-cut coal mine. Atmos Environ. 2020;229:117471.
Wannamethee SG, Shaper AG, Papacosta O, Lennon L, Welsh P, Whincup PH. Lung function and airway obstruction: associations with circulating markers of cardiac function and incident heart failure in older men-the British Regional Heart Study. Thorax. 2016;71:526-34.
Oostveen E, MacLeod D, Lorino H, Farre R, Hantos Z, Desager K, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003;22:1026-41.
Lu Y, Sooky L, Silva MJ, Molaodi OR, Karamanos A, Cruickshank JK, et al. Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multiethnic cohort. J Hypertens. 2017;35:2185-91.
Masi S, Taddei S. Understanding the relationship between lung function and cardiovascular phenotypes in the young: opportunity for a better cardiovascular risk prevention in adulthood? J Hypertens. 2017;35:2171-4.
Macnee W, Maclay J, McAllister D. Cardiovascular injury and repair in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008;5:824-33.
Barr RG, Mesia-Vela S, Austin JH, Basner RC, Keller BM, Reeves AP, et al. Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: the Emphysema and Cancer Action Project (EMCAP) study. Am J Respir Crit Care Med. 2007;176:1200-7.
Postma DS, Bush A, van den Berge M. Risk factors and early origins of chronic obstructive pulmonary disease. Lancet. 2015;385:899-909.
Luo X, Yang Y, Cao T, Li Z. Differences in left and right carotid intima-media thickness and the associated risk factors. Clin Radiol. 2011;66:393-8.
Selwaness M, van den Bouwhuijsen Q, van Onkelen RS, Hofman A, Franco OH, van der Lugt A, et al. Atherosclerotic plaque in the left carotid artery is more vulnerable than in the right. Stroke. 2014;45:3226-30.
Lind L, Andersson J, Larsson A, Sandhagen B. Shear stress in the common carotid artery is related to both intima-media thickness and echogenecity. The Prospective Investigation of the Vasculature in Uppsala Seniors study. Clin Hemorheol Microcirc. 2009;43:299-308.
Arikan S, Akay H, Bahceci M, Tuzcu A, Gokalp D. The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function. Fertil Steril. 2009;91:450-5.
Yu Y, Arah OA, Liew Z, Cnattingius S, Olsen J, Sørensen HT, et al. Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up. BMJ. 2019;367:l6398.
Azad MB, Moyce BL, Guillemette L, Pascoe CD, Wicklow B, McGavock JM, et al. Diabetes in pregnancy and lung health in offspring: developmental origins of respiratory disease. Paediatr Respir Rev. 2017;21:19-26.
Martinez FD. Early-life origins of chronic obstructive pulmonary disease. N Engl J Med. 2016;375:871-8.