Nuclear receptors in liver fibrosis.
AR
ER
FXR
GR
LXR
Liver fibrosis
MR
Nuclear receptor
PPAR
RAR
RXR
THR
VDR
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
received:
26
04
2021
revised:
18
07
2021
accepted:
27
07
2021
pubmed:
3
8
2021
medline:
31
12
2021
entrez:
2
8
2021
Statut:
ppublish
Résumé
Nuclear receptors are ligand-activated transcription factors that regulate gene expression of a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver fibrogenesis is activated hepatic stellate cells. Different nuclear receptors regulate the hepatic expression of pro-inflammatory and pro-fibrogenic cytokines that promote the transformation of hepatic stellate cells into fibrogenic myofibroblasts. Importantly, nuclear receptors regulate gene expression circuits that promote hepatic fibrogenesis and/or allow liver fibrosis regression. In this review, we highlight the direct and indirect influence of nuclear receptors on liver fibrosis, with a focus on hepatic stellate cells, and discuss potential therapeutic effects of nuclear receptor modulation in regard to anti-fibrotic and anti-inflammatory effects. Further research on nuclear receptors-related signaling may lead to the clinical development of effective anti-fibrotic therapies for patients with liver disease.
Identifiants
pubmed: 34339839
pii: S0925-4439(21)00168-X
doi: 10.1016/j.bbadis.2021.166235
pii:
doi:
Substances chimiques
Ligands
0
Receptors, Cytoplasmic and Nuclear
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
166235Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.