Rutin promotes activation and reduces apoptosis of primordial follicles by regulating Akt phosphorylation after in vitro culture of ovine ovarian tissue.

Animals Apoptosis Female Phosphatidylinositol 3-Kinases / metabolism Phosphorylation Proto-Oncogene Proteins c-akt / metabolism Rutin / pharmacology Sheep Tissue Culture Techniques / veterinary
Flavonoid Oocyte PI3K pathway Sheep Vitamin P

Journal

Theriogenology
ISSN: 1879-3231
Titre abrégé: Theriogenology
Pays: United States
ID NLM: 0421510

Informations de publication

Date de publication:
01 Oct 2021
Historique:
received: 08 02 2021
revised: 09 06 2021
accepted: 25 07 2021
pubmed: 3 8 2021
medline: 27 8 2021
entrez: 2 8 2021
Statut: ppublish

Résumé

The aims of this study were to analyze the effects of different concentrations of rutin on primordial follicle survival and development after in vitro culture of sheep ovarian tissue, and to verify the possible involvement of the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway in the rutin actions. Ovarian fragments were fixed for histological analysis (fresh control) or cultured in α-minimum essential medium alone (α-MEM

Identifiants

DOI: 10.1016/j.theriogenology.2021.07.018 PMID: 34339905
pubmed: 34339905
pii: S0093-691X(21)00243-0
doi: 10.1016/j.theriogenology.2021.07.018
pii:
doi:

Substances chimiques

Rutin 5G06TVY3R7
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

64-72

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

T L B G Lins (TLBG)

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil.

R S Barberino (RS)

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil.

A P O Monte (APO)

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil.

J G C Pinto (JGC)

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil.

D S P Campinho (DSP)

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil.

R C Palheta (RC)

Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Federal University of São Francisco Valley, Petrolina, PE, Brazil.

M H T Matos (MHT)

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil. Electronic address: helena.matos@univasf.edu.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Rutin promotes activation and reduces...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Rutin promotes activation and reduces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Rutin promotes activation and reduces...
questionsmedicales.fr › Métabolisme › Phosphorylation › Rutin promotes activation and reduces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Rutin promotes activation and reduces...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Rutoside › Rutin promotes activation and reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Rutin promotes activation and reduces...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture de tissus › Rutin promotes activation and reduces...