Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm.
Adolescent
Adolescent Development
/ physiology
Cerebellum
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Female
Follow-Up Studies
Functional Laterality
/ physiology
Functional Neuroimaging
Humans
Infant, Extremely Premature
/ physiology
Magnetic Resonance Imaging
Male
Psychomotor Performance
/ physiology
Fine motor
Follow-up
Prematurity
fMRI
Journal
Pediatric neurology
ISSN: 1873-5150
Titre abrégé: Pediatr Neurol
Pays: United States
ID NLM: 8508183
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
21
04
2021
revised:
28
06
2021
accepted:
03
07
2021
pubmed:
3
8
2021
medline:
22
2
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
Fine motor and coordination problems are frequently reported among adolescents born preterm. We aimed to assess performance in hand coordination tasks and to compare concurrent brain activation between adolescents born very preterm and at term at 13 years. A total of 34 right-handed adolescents born very preterm (gestational age less than 32 weeks/birth weight ≤1500 grams) and 37 controls born at term during 2003 to 2006 in Turku University Hospital, Finland, were recruited. At 13 years, finger opposition and diadochokinesis were assessed, and brain functional magnetic resonance imaging data were acquired while the adolescents performed unimanual hand coordination tasks in response to visual cue. Adolescents born very preterm performed similar to controls in hand coordination tasks. The very preterm group evoked greater brain activation than the controls in the right precentral gyrus and in the right postcentral gyrus during left-hand finger opposition and in the right postcentral gyrus during left-hand diadochokinesis. Within the very preterm group, lower gestational age was associated with reduced activation in the left superior parietal lobule during right-hand diadochokinesis. Regarding left-hand tasks, lower gestational age was associated with stronger activation in the right cerebellar lobule V and left cerebellar lobule VI during finger opposition and stronger activation in the right superior parietal lobule during diadochokinesis. Very preterm birth affected hand coordination-related brain activation. Most of the effects were found for nondominant hand. Clinical performance during the hand coordination tasks was similar in adolescents born very preterm and controls.
Sections du résumé
BACKGROUND
Fine motor and coordination problems are frequently reported among adolescents born preterm. We aimed to assess performance in hand coordination tasks and to compare concurrent brain activation between adolescents born very preterm and at term at 13 years.
METHODS
A total of 34 right-handed adolescents born very preterm (gestational age less than 32 weeks/birth weight ≤1500 grams) and 37 controls born at term during 2003 to 2006 in Turku University Hospital, Finland, were recruited. At 13 years, finger opposition and diadochokinesis were assessed, and brain functional magnetic resonance imaging data were acquired while the adolescents performed unimanual hand coordination tasks in response to visual cue.
RESULTS
Adolescents born very preterm performed similar to controls in hand coordination tasks. The very preterm group evoked greater brain activation than the controls in the right precentral gyrus and in the right postcentral gyrus during left-hand finger opposition and in the right postcentral gyrus during left-hand diadochokinesis. Within the very preterm group, lower gestational age was associated with reduced activation in the left superior parietal lobule during right-hand diadochokinesis. Regarding left-hand tasks, lower gestational age was associated with stronger activation in the right cerebellar lobule V and left cerebellar lobule VI during finger opposition and stronger activation in the right superior parietal lobule during diadochokinesis.
CONCLUSIONS
Very preterm birth affected hand coordination-related brain activation. Most of the effects were found for nondominant hand. Clinical performance during the hand coordination tasks was similar in adolescents born very preterm and controls.
Identifiants
pubmed: 34339952
pii: S0887-8994(21)00142-9
doi: 10.1016/j.pediatrneurol.2021.07.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-29Investigateurs
Mikael Ekblad
(M)
Satu Ekblad
(S)
Eeva Ekholm
(E)
Linda Grönroos
(L)
Leena Haataja
(L)
Mira Huhtala
(M)
Jere Jaakkola
(J)
Eveliina Joensuu
(E)
Pentti Kero
(P)
Riikka Korja
(R)
Katri Lahti
(K)
Helena Lapinleimu
(H)
Liisa Lehtonen
(L)
Tuomo Lehtonen
(T)
Marika Leppänen
(M)
Annika Lind
(A)
Jaakko Matomäki
(J)
Jonna Maunu
(J)
Petriina Munck
(P)
Laura Määttänen
(L)
Pekka Niemi
(P)
Anna Nyman
(A)
Pertti Palo
(P)
Riitta Parkkola
(R)
Liisi Ripatti
(L)
Päivi Rautava
(P)
Katriina Saarinen
(K)
Tiina Saarinen
(T)
Virva Saunavaara
(V)
Sirkku Setänen
(S)
Matti Sillanpää
(M)
Suvi Stolt
(S)
Päivi Tuomikoski-Koiranen
(P)
Timo Tuovinen
(T)
Karoliina Uusitalo
(K)
Anniina Väliaho
(A)
Milla Ylijoki
(M)
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.