Aqueous stability and degradation of psychiatric and neuroactive compounds and its biological activity in Daphnia magna.

Pharmaceuticals and other emerging contaminants are continuously released into the aquatic environment, considered as 'pseudo-persistent' pollutants. Many compounds degrade fast in the environment, but sometimes their transformation products (TPs) are equally or even more toxic than the parental compounds, raising concern about the potential risks to the environment. In this way, the crustacean Daphnia magna (D. magna) is one of the most widely used organisms in aquatic toxicology studies, since it is an interesting non-vertebrate model to study via neurotransmitters the toxicological consequences of contaminants. In this study, the stability in water of 17 neuroactive compounds using ultra-high-performance liquid chromatography (UHPLC) coupled to a MS/MS detector was evaluated. In order to assess the stability of the compounds, samples of 1 ng μL

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.