The role of TGF-β2 in cartilage development and diseases.
Cartilage development and diseases
Chondrocyte
TGF-β2
apoptosis
blood vessels
cartilage defects
cartilage diseases
cartilage tissue
chondrocytes
cytokines
growth factors
mesenchymal progenitor cells
osteoarthritis (OA)
Journal
Bone & joint research
ISSN: 2046-3758
Titre abrégé: Bone Joint Res
Pays: England
ID NLM: 101586057
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
entrez:
3
8
2021
pubmed:
4
8
2021
medline:
4
8
2021
Statut:
ppublish
Résumé
Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its counterpart, TGF-β1. Cartilage as a load-resisting structure in vertebrates however displays a fragile performance when any tissue disturbance occurs, due to its lack of blood vessels, nerves, and lymphatics. Recent reports have indicated that TGF-β2 is involved in the physiological processes of chondrocytes such as proliferation, differentiation, migration, and apoptosis, and the pathological progress of cartilage such as osteoarthritis (OA) and rheumatoid arthritis (RA). TGF-β2 also shows its potent capacity in the repair of cartilage defects by recruiting autologous mesenchymal stem cells and promoting secretion of other growth factor clusters. In addition, some pioneering studies have already considered it as a potential target in the treatment of OA and RA. This article aims to summarize the current progress of TGF-β2 in cartilage development and diseases, which might provide new cues for remodelling of cartilage defect and intervention of cartilage diseases.
Identifiants
pubmed: 34340528
doi: 10.1302/2046-3758.108.BJR-2021-0086
pmc: PMC8412840
doi:
Types de publication
Journal Article
Langues
eng
Pagination
474-487Références
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