Neurologic and Cognitive Outcomes in Sickle Cell Disease from Infancy through Adolescence.


Journal

NeoReviews
ISSN: 1526-9906
Titre abrégé: Neoreviews
Pays: United States
ID NLM: 101085360

Informations de publication

Date de publication:
08 2021
Historique:
entrez: 3 8 2021
pubmed: 4 8 2021
medline: 3 11 2021
Statut: ppublish

Résumé

Children with sickle cell disease (SCD) are at risk for neurologic and cognitive complications beginning in early childhood. Current treatment for SCD focuses on primary prevention of complications, such as hydroxyurea for prevention of pain and acute chest syndrome, and chronic transfusion therapy for children who are at high risk for strokes. In this article, the prevalence, pathophysiology, and available interventions to prevent and treat neurologic and cognitive complications of SCD will be reviewed.

Identifiants

pubmed: 34341160
pii: 22/8/e531
doi: 10.1542/neo.22-8-e531
doi:

Substances chimiques

Antisickling Agents 0
Hydroxyurea X6Q56QN5QC

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e531-e539

Subventions

Organisme : NHLBI NIH HHS
ID : K23 HL136904
Pays : United States

Informations de copyright

Copyright © 2021 by the American Academy of Pediatrics.

Auteurs

Sarah L Mayer (SL)

Children's Hospital of Philadelphia, Philadelphia, PA.

Melanie E Fields (ME)

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University in St Louis, St Louis, MO.

Monica L Hulbert (ML)

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University in St Louis, St Louis, MO.

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Classifications MeSH