Genome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
02 08 2021
02 08 2021
Historique:
received:
24
01
2021
accepted:
26
07
2021
revised:
13
07
2021
entrez:
3
8
2021
pubmed:
4
8
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Depression is currently the leading cause of disability around the world. We conducted an epigenome-wide association study (EWAS) in a sample of 58 depression score-discordant monozygotic twin pairs, aiming to detect specific epigenetic variants potentially related to depression and further integrate with gene expression profile data. Association between the methylation level of each CpG site and depression score was tested by applying a linear mixed effect model. Weighted gene co-expression network analysis (WGCNA) was performed for gene expression data. The association of DNA methylation levels of 66 CpG sites with depression score reached the level of P < 1 × 10
Identifiants
pubmed: 34341332
doi: 10.1038/s41398-021-01536-y
pii: 10.1038/s41398-021-01536-y
pmc: PMC8329295
doi:
Substances chimiques
Biomarkers
0
Hedgehog Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
416Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82073641
Informations de copyright
© 2021. The Author(s).
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