Mendelian randomisation study of smoking exposure in relation to breast cancer risk.

Breast Neoplasms / epidemiology Case-Control Studies Cigarette Smoking / adverse effects Female Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Genotyping Techniques Humans Mendelian Randomization Analysis Polymorphism, Single Nucleotide

Journal

British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635

Informations de publication

Date de publication:
10 2021
Historique:
received: 03 08 2020
accepted: 28 04 2021
revised: 14 04 2021
pubmed: 4 8 2021
medline: 18 12 2021
entrez: 3 8 2021
Statut: ppublish

Résumé

Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10 Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.

Sections du résumé

BACKGROUND
Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk.
METHODS
We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy.
RESULTS
Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10
CONCLUSION
Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.

Identifiants

DOI: 10.1038/s41416-021-01432-8 PMID: 34341517 PMC: PMC8505411
pubmed: 34341517
doi: 10.1038/s41416-021-01432-8
pii: 10.1038/s41416-021-01432-8
pmc: PMC8505411
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1135-1145

Subventions

Organisme : Medical Research Council
ID : MC_UU_00004/02
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29186
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P50 CA058223
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom

Investigateurs

Anne-Lise Børresen-Dale (AL)
Grethe I Grenaker Alnæs (GI)
Kristine K Sahlberg (KK)
Lars Ottestad (L)
Rolf Kåresen (R)
Ellen Schlichting (E)
Marit Muri Holmen (MM)
Toril Sauer (T)
Vilde Haakensen (V)
Olav Engebråten (O)
Bjørn Naume (B)
Alexander Fosså (A)
Cecile E Kiserud (CE)
Kristin V Reinertsen (KV)
Åslaug Helland (Å)
Margit Riis (M)
Jürgen Geisler (J)
Christine Clarke (C)
Deborah Marsh (D)
Rodney Scott (R)
Robert Baxter (R)
Desmond Yip (D)
Jane Carpenter (J)
Alison Davis (A)
Nirmala Pathmanathan (N)
Peter Simpson (P)
Dinny Graham (D)
Mythily Sachchithananthan (M)
David Amor (D)
Lesley Andrews (L)
Yoland Antill (Y)
Rosemary Balleine (R)
Jonathan Beesley (J)
Ian Bennett (I)
Michael Bogwitz (M)
Leon Botes (L)
Meagan Brennan (M)
Melissa Brown (M)
Michael Buckley (M)
Jo Burke (J)
Phyllis Butow (P)
Liz Caldon (L)
Ian Campbell (I)
Deepa Chauhan (D)
Manisha Chauhan (M)
Georgia Chenevix-Trench (G)
Alice Christian (A)
Paul Cohen (P)
Alison Colley (A)
Ashley Crook (A)
James Cui (J)
Margaret Cummings (M)
Sarah-Jane Dawson (SJ)
Anna DeFazio (A)
Martin Delatycki (M)
Rebecca Dickson (R)
Joanne Dixon (J)
Ted Edkins (T)
Stacey Edwards (S)
Gelareh Farshid (G)
Andrew Fellows (A)
Georgina Fenton (G)
Michael Field (M)
James Flanagan (J)
Peter Fong (P)
Laura Forrest (L)
Stephen Fox (S)
Juliet French (J)
Michael Friedlander (M)
Clara Gaff (C)
Mike Gattas (M)
Peter George (P)
Sian Greening (S)
Marion Harris (M)
Stewart Hart (S)
Nick Hayward (N)
John Hopper (J)
Cass Hoskins (C)
Clare Hunt (C)
Paul James (P)
Mark Jenkins (M)
Alexa Kidd (A)
Judy Kirk (J)
Jessica Koehler (J)
James Kollias (J)
Sunil Lakhani (S)
Mitchell Lawrence (M)
Geoff Lindeman (G)
Lara Lipton (L)
Liz Lobb (L)
Graham Mann (G)
Deborah Marsh (D)
Sue Anne McLachlan (SA)
Bettina Meiser (B)
Roger Milne (R)
Sophie Nightingale (S)
Shona O'Connell (S)
Sarah O'Sullivan (S)
David Gallego Ortega (DG)
Nick Pachter (N)
Briony Patterson (B)
Amy Pearn (A)
Kelly Phillips (K)
Ellen Pieper (E)
Edwina Rickard (E)
Bridget Robinson (B)
Mona Saleh (M)
Elizabeth Salisbury (E)
Christobel Saunders (C)
Jodi Saunus (J)
Rodney Scott (R)
Clare Scott (C)
Adrienne Sexton (A)
Andrew Shelling (A)
Peter Simpson (P)
Melissa Southey (M)
Amanda Spurdle (A)
Jessica Taylor (J)
Renea Taylor (R)
Heather Thorne (H)
Alison Trainer (A)
Kathy Tucker (K)
Jane Visvader (J)
Logan Walker (L)
Rachael Williams (R)
Ingrid Winship (I)
Mary Ann Young (MA)

Informations de copyright

© 2021. The Author(s).

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Auteurs

Hanla A Park (HA)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0001-8055-3729

Sonja Neumeyer (S)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Kyriaki Michailidou (K)

Biostatistics Unit, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.
Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Manjeet K Bolla (MK)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Qin Wang (Q)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-4591-1214

Thomas U Ahearn (TU)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Irene L Andrulis (IL)

Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Hoda Anton-Culver (H)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.

Natalia N Antonenkova (NN)

N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.

Volker Arndt (V)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Kristan J Aronson (KJ)

Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, Canada.

Annelie Augustinsson (A)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
ORCID: 0000-0003-3415-0536

Adinda Baten (A)

Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Laura E Beane Freeman (LE)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Heiko Becher (H)

Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Biometry and Clinical Epidemiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Sabine Behrens (S)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Javier Benitez (J)

Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Marina Bermisheva (M)

Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.

Natalia V Bogdanova (NV)

N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Stig E Bojesen (SE)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Hiltrud Brauch (H)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
iFIT-Cluster of Excellence, University of Tübingen, Tübingen, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Partner Site Tübingen, Tübingen, Germany.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-6129-1572

Sara Y Brucker (SY)

Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany.

Barbara Burwinkel (B)

Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany.

Daniele Campa (D)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Biology, University of Pisa, Pisa, Italy.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-4261-4583

Jose E Castelao (JE)

Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Georgia Chenevix-Trench (G)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Christine L Clarke (CL)

Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia.

Don M Conroy (DM)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Fergus J Couch (FJ)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Angela Cox (A)

Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
ORCID: 0000-0002-5138-1099

Simon S Cross (SS)

Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.

Kamila Czene (K)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Mary B Daly (MB)

Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.

Peter Devilee (P)

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
ORCID: 0000-0002-8023-2009

Thilo Dörk (T)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Isabel Dos-Santos-Silva (I)

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Miriam Dwek (M)

School of Life Sciences, University of Westminster, London, UK.

Diana M Eccles (DM)

Faculty of Medicine, University of Southampton, Southampton, UK.

A Heather Eliassen (AH)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Christoph Engel (C)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

Mikael Eriksson (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

D Gareth Evans (DG)

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0003-4885-8471

Henrik Flyger (H)

Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Lin Fritschi (L)

School of Public Health, Curtin University, Perth, WA, Australia.

Montserrat García-Closas (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

José A García-Sáenz (JA)

Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

Mia M Gaudet (MM)

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Gord Glendon (G)

Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.

Mark S Goldberg (MS)

Department of Medicine, McGill University, Montréal, QC, Canada.
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, QC, Canada.

David E Goldgar (DE)

Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Anna González-Neira (A)

Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Mervi Grip (M)

Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.

Pascal Guénel (P)

Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.

Eric Hahnen (E)

Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Niclas Håkansson (N)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Per Hall (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Oncology, Södersjukhuset, Stockholm, Sweden.

Ute Hamann (U)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Sileny Han (S)

Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Elaine F Harkness (EF)

Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Nightingale & Genesis Prevention Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
NIHR Manchester Biomedical Research Unit, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
ORCID: 0000-0001-6625-7739

Steven N Hart (SN)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0001-7714-2734

Wei He (W)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Bernadette A M Heemskerk-Gerritsen (BAM)

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
ORCID: 0000-0002-9724-6693

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

David J Hunter (DJ)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Agnes Jager (A)

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Anna Jakubowska (A)

Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
ORCID: 0000-0002-5650-0501

Esther M John (EM)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Audrey Jung (A)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Pooja Middha Kapoor (PM)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0001-5503-8215

Renske Keeman (R)

Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Elza Khusnutdinova (E)

Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.

Cari M Kitahara (CM)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Linetta B Koppert (LB)

Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Stella Koutros (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Vessela N Kristensen (VN)

Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Allison W Kurian (AW)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0002-6175-9470

James Lacey (J)

Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.

Diether Lambrechts (D)

VIB Center for Cancer Biology, Leuven, Belgium.
Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.

Loic Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Wing-Yee Lo (WY)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
University of Tübingen, Tübingen, Germany.

Jan Lubiński (J)

Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

Arto Mannermaa (A)

Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.

Mehdi Manoochehri (M)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Sara Margolin (S)

Department of Oncology, Södersjukhuset, Stockholm, Sweden.
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Maria Elena Martinez (ME)

Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.

Dimitrios Mavroudis (D)

Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.

Alfons Meindl (A)

Department of Gynecology and Obstetrics, University of Munich, Campus Großhadern, Munich, Germany.

Usha Menon (U)

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Taru A Muranen (TA)

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Heli Nevanlinna (H)

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

William G Newman (WG)

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
ORCID: 0000-0002-6382-4678

Børge G Nordestgaard (BG)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Kenneth Offit (K)

Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Andrew F Olshan (AF)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Håkan Olsson (H)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.

Tjoung-Won Park-Simon (TW)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Paolo Peterlongo (P)

Genome Diagnostics Program, IFOM - the FIRC Institute of Molecular Oncology, Milan, Italy.
ORCID: 0000-0001-6951-6855

Julian Peto (J)

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
ORCID: 0000-0002-1685-8912

Dijana Plaseska-Karanfilska (D)

Research Centre for Genetic Engineering and Biotechnology 'Georgi D, Efremov', MASA, Skopje, Republic of North Macedonia.

Nadege Presneau (N)

School of Life Sciences, University of Westminster, London, UK.

Paolo Radice (P)

Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.

Gad Rennert (G)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.

Hedy S Rennert (HS)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.

Atocha Romero (A)

Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Emmanouil Saloustros (E)

Department of Oncology, University Hospital of Larissa, Larissa, Greece.

Elinor J Sawyer (EJ)

School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, UK.
ORCID: 0000-0001-8285-4111

Marjanka K Schmidt (MK)

Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.

Rita K Schmutzler (RK)

Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Minouk J Schoemaker (MJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Lukas Schwentner (L)

Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.

Christopher Scott (C)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0003-1340-0647

Mitul Shah (M)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Jacques Simard (J)

Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, Canada.

Ann Smeets (A)

Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium.
ORCID: 0000-0002-5091-6602

Melissa C Southey (MC)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.

John J Spinelli (JJ)

Population Oncology, BC Cancer, Vancouver, BC, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Victoria Stevens (V)

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.

Anthony J Swerdlow (AJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.

Rulla M Tamimi (RM)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

William J Tapper (WJ)

Faculty of Medicine, University of Southampton, Southampton, UK.

Jack A Taylor (JA)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Mary Beth Terry (MB)

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

Ian Tomlinson (I)

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
ORCID: 0000-0003-3037-1470

Melissa A Troester (MA)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Thérèse Truong (T)

Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
ORCID: 0000-0002-2943-6786

Celine M Vachon (CM)

Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Elke M van Veen (EM)

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Joseph Vijai (J)

Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Sophia Wang (S)

Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.

Camilla Wendt (C)

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Robert Winqvist (R)

Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Argyrios Ziogas (A)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.

Alison M Dunning (AM)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Paul D P Pharoah (PDP)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-8494-732X

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Peter Kraft (P)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. j.chang-claude@dkfz.de.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. j.chang-claude@dkfz.de.

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questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Mendelian randomisation study of smoking...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Mendelian randomisation study of smoking...
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