Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.

Brain / metabolism Diabetes Mellitus / etiology Energy Metabolism Ependymoglial Cells / metabolism ErbB Receptors / metabolism Insulin-Secreting Cells / metabolism Leptin / metabolism Lipid Metabolism Pancreas / metabolism Phosphorylation Receptors, Leptin / metabolism

Journal

Nature metabolism

ISSN: 2522-5812

Titre abrégé: Nat Metab

Pays: Germany

ID NLM: 101736592

Informations de publication

Date de publication:
08 2021

Historique:

received: 12 11 2019

accepted: 23 06 2021

pubmed: 4 8 2021

medline: 5 10 2021

entrez: 3 8 2021

Statut: ppublish

Résumé

Metabolic health depends on the brain's ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain barriers and mobilize regulatory circuits. We have previously shown that hypothalamic tanycytes shuttle leptin into the brain to reach target neurons. Here, using multiple complementary models, we show that tanycytes express functional leptin receptor (LepR), respond to leptin by triggering Ca

Identifiants

DOI: 10.1038/s42255-021-00432-5 PMID: 34341568 PMC: PMC7611554

pubmed: 34341568

doi: 10.1038/s42255-021-00432-5

pii: 10.1038/s42255-021-00432-5

pmc: PMC7611554

mid: EMS128607

doi:

Substances chimiques

Leptin 0

Receptors, Leptin 0

ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1071-1090

Subventions

Organisme : NIDDK NIH HHS

ID : R01 DK123002

Pays : United States

Organisme : European Research Council

ID : 810331

Pays : International

Informations de copyright

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