Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.


Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
27 Jul 2021
Historique:
entrez: 3 8 2021
pubmed: 4 8 2021
medline: 4 8 2021
Statut: epublish

Résumé

We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (

Identifiants

pubmed: 34341784
doi: 10.21203/rs.3.rs-673011/v1
pmc: PMC8328070
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM138201
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR076241
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM010098
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM113657
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK019525
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104339
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM134957
Pays : United States

Commentaires et corrections

Type : UpdateIn

Références

JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Bioinformatics. 2010 May 1;26(9):1205-10
pubmed: 20335276
Science. 2006 Jun 16;312(5780):1614-20
pubmed: 16778047
Nat Microbiol. 2020 Apr;5(4):562-569
pubmed: 32094589
J Mol Cell Cardiol. 2020 Oct;147:12-17
pubmed: 32771409
J Virol. 2014 Jan;88(2):1293-307
pubmed: 24227843
Mol Biol Evol. 2009 Feb;26(2):273-83
pubmed: 18922762
Nat Microbiol. 2020 Nov;5(11):1330-1339
pubmed: 32704094
Sci Rep. 2020 Oct 6;10(1):16642
pubmed: 33024235
Epigenomics. 2012 Jun;4(3):317-24
pubmed: 22690667
Hypertens Res. 2020 Aug;43(8):854-856
pubmed: 32439915
Exp Mol Med. 2018 Aug 7;50(8):1-8
pubmed: 30089779
Science. 2009 May 22;324(5930):1035-44
pubmed: 19407144
Nature. 1991 Jun 20;351(6328):652-4
pubmed: 1904993
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22035-22041
pubmed: 32820077
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Nucleic Acids Res. 2003 Jul 1;31(13):3812-4
pubmed: 12824425
Emerg Infect Dis. 2020 Jul;26(7):
pubmed: 32364890
Cell Discov. 2020 Feb 24;6:11
pubmed: 32133153
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Nucleic Acids Res. 2014 Jan;42(1):87-96
pubmed: 24089144
J Biol Chem. 2001 Jan 12;276(2):857-60
pubmed: 11060317
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Nat Genet. 2017 May;49(5):700-707
pubmed: 28394350
JAMA. 2020 Apr 28;323(16):1612-1614
pubmed: 32191259
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3596-603
pubmed: 25136101
Heart Rhythm. 2020 Sep;17(9):1463-1471
pubmed: 32387246
Pac Symp Biocomput. 2016;21:249-60
pubmed: 26776191
Nature. 2007 Oct 18;449(7164):913-8
pubmed: 17943131
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1160-5
pubmed: 20080661
Am J Hum Genet. 2011 Apr 8;88(4):440-9
pubmed: 21457909
Mol Biol Evol. 2014 Oct;31(10):2824-7
pubmed: 25015648
PLoS Biol. 2006 Mar;4(3):e72
pubmed: 16494531
J Virol. 2011 May;85(9):4122-34
pubmed: 21325420
Ann Intern Med. 2021 Feb;174(2):286-287
pubmed: 33587872
Nature. 2020 Jul;583(7818):699-710
pubmed: 32728249
J Clin Med. 2020 Jul 30;9(8):
pubmed: 32751633
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Mol Biol Evol. 1986 Sep;3(5):418-26
pubmed: 3444411
Nat Rev Genet. 2013 Oct;14(10):692-702
pubmed: 24052086
JAMA Cardiol. 2020 Jul 1;5(7):802-810
pubmed: 32211816
Nature. 2012 Feb 05;482(7385):390-4
pubmed: 22307276
Diabetes Res Clin Pract. 2020 Jul;165:108227
pubmed: 32446795
PLoS Genet. 2020 Apr 20;16(4):e1008662
pubmed: 32310939
EClinicalMedicine. 2020 Jun 25;24:100434
pubmed: 32766543
JAMA. 2020 May 19;323(19):1891-1892
pubmed: 32293639
Nat Genet. 2015 Feb;47(2):126-31
pubmed: 25581429
J Mol Neurosci. 2021 Nov;71(11):2192-2209
pubmed: 33464535
Lancet Diabetes Endocrinol. 2020 Sep;8(9):782-792
pubmed: 32687793
Int J Mol Med. 2021 Mar;47(3):
pubmed: 33448315
Nat Genet. 2016 Jul;48(7):811-6
pubmed: 27270109
Nucleic Acids Res. 2019 Jan 8;47(D1):D886-D894
pubmed: 30371827
Emerg Microbes Infect. 2020 Dec;9(1):601-604
pubmed: 32178593
PLoS Pathog. 2020 Jun 22;16(6):e1008570
pubmed: 32569293
Nat Rev Microbiol. 2016 Aug;14(8):523-34
pubmed: 27344959
Neuroradiol J. 2021 Aug;34(4):308-312
pubmed: 33455541
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
PLoS Genet. 2013;9(8):e1003649
pubmed: 23935528
Mol Biol Evol. 2003 Mar;20(3):424-34
pubmed: 12644563
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
BMC Med Genomics. 2013;6 Suppl 2:S6
pubmed: 23819467
PLoS Genet. 2018 Aug 10;14(8):e1007586
pubmed: 30096133
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
Cell. 2019 Mar 21;177(1):26-31
pubmed: 30901543
PLoS Genet. 2008 Dec;4(12):e1000304
pubmed: 19081788
Am J Hum Genet. 2011 Jul 15;89(1):82-93
pubmed: 21737059
Sci Rep. 2018 Mar 15;8(1):4624
pubmed: 29545597
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Nucleic Acids Res. 2020 Jan 8;48(D1):D180-D188
pubmed: 31665499
Med Hypotheses. 2021 Jan;146:110371
pubmed: 33223324
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Circulation. 2020 Aug 18;142(7):708-710
pubmed: 32795091
Am J Hum Genet. 2012 Aug 10;91(2):224-37
pubmed: 22863193
BMC Med. 2020 Jul 15;18(1):216
pubmed: 32664879
Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20
pubmed: 23315928
PLoS Pathog. 2020 May 22;16(5):e1008536
pubmed: 32442210
Eur J Intern Med. 2020 Jun;76:14-20
pubmed: 32336612
Nature. 2021 Feb;590(7845):290-299
pubmed: 33568819
Eur J Hum Genet. 2020 Nov;28(11):1602-1614
pubmed: 32681121

Auteurs

Chao Zhang (C)

University of Pennsylvania.

Anurag Verma (A)

Perelman School of Medicine, University of Pennsylvania.

Yuanqing Feng (Y)

University of Pennsylvania.

Michael McQuillan (M)

University of Pennsylvania.

Matthew Hansen (M)

University of Pennsylvania.

Anastasia Lucas (A)

University of Pennsylvania.

Joseph Park (J)

Perelman School of Medicine, University of Pennsylvania.

Alessia Ranciaro (A)

University of Pennsylvania.

Simon Thompson (S)

University of Pennsylvania.

Meghan Rubel (M)

University of Pennsylvania.

Michael Campbell (M)

Howard University.

William Beggs (W)

University of Pennsylvania.

Jibril Hirbo (J)

Vanderbilt University School of Medicine.

Sununguko Wata Mpoloka (SW)

University of Botswana.

Gaonyadiwe George Mokone (GG)

University of Botswana.

Marcus Jones (M)

Human Longevity (United States).

Thomas Nyambo (T)

Muhimbili University of Health and Allied Sciences.

Dawit Wolde Meskel (DW)

Addis Ababa University Department of Microbial Cellular and Molecular Biology.

Guija Belay (G)

Addis Ababa University Department of Microbial Cellular and Molecular Biology.

Charles Fokunang (C)

Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.

Alfred Njamnshi (A)

The University of Yaoundé I.

Sabah Omar (S)

Kenya Medical Research Institute.

Daniel Rader (D)

Perelman School of Medicine at the University of Pennsylvania.

Marylyn Ritchie (M)

University of Pennsylvania.

Giorgio Sirugo (G)

University of Pennsylvania.

Sarah Tishkoff (S)

University of Pennsylvania.

Classifications MeSH