SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
26 Jan 2022
26 Jan 2022
Historique:
pubmed:
4
8
2021
medline:
4
8
2021
entrez:
3
8
2021
Statut:
epublish
Résumé
Although mRNA vaccine efficacy against severe COVID-19 remains high, variant emergence and breakthrough infections have changed vaccine policy to include booster immunizations. However, the effect of diverse and repeated antigen exposures on SARS-CoV-2 memory T cells is poorly understood. Here, we utilize DNA-barcoded MHC-multimers combined with scRNAseq and scTCRseq to capture the
Identifiants
pubmed: 34341799
doi: 10.1101/2021.07.12.21260227
pmc: PMC8328067
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00052
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136514
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI144616
Pays : United States
Commentaires et corrections
Type : UpdateIn
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