Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage.
Articular cartilage
Finite element analysis
Mechanical properties
Mechanical testing
OARSI grading
Osteoarthritis
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
17
03
2021
accepted:
15
07
2021
pubmed:
4
8
2021
medline:
27
1
2022
entrez:
3
8
2021
Statut:
ppublish
Résumé
Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to determine the severity of histopathological cartilage degradation. The results suggest that alterations in the FRPE properties are not evident in the moderate stages of cartilage degradation (OARSI 2-3) as compared with normal tissue (OARSI 0-1). Drastic deterioration of the FRPE properties was observed in severely degraded cartilage (OARSI 4). We also found that the FRPE properties of femoral condyle cartilage related to the collagen network (initial fibril-network modulus) and proteoglycan matrix (non-fibrillar matrix modulus) were greater compared to tibial and patellar cartilage in OA. These findings may inform cartilage tissue-engineering efforts and help to improve the accuracy of cartilage representations in computational knee joint models.
Identifiants
pubmed: 34341898
doi: 10.1007/s10439-021-02838-4
pii: 10.1007/s10439-021-02838-4
pmc: PMC8455392
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2622-2634Subventions
Organisme : Academy of Finland
ID : 286526
Organisme : Academy of Finland
ID : 324529
Organisme : Academy of Finland
ID : 268378
Organisme : Suomen Kulttuurirahasto
ID : 65191841
Organisme : Suomen Kulttuurirahasto
ID : 191044
Organisme : Emil Aaltosen Säätiö
ID : 200016
Organisme : Alfred Kordelinin Säätiö
ID : 190111
Organisme : alfred kordelinin säätiö
ID : 190317
Informations de copyright
© 2021. The Author(s).
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