Association between Parental Cotinine-verified Smoking Status and Childhood Asthma: a Population-based Nationally Representative Analysis.
Adult
Alcohol Drinking
/ epidemiology
Asthma
/ epidemiology
Child
Cotinine
/ urine
Cross-Sectional Studies
Environmental Exposure
/ adverse effects
Female
Humans
Incidence
Male
Middle Aged
Nutrition Surveys
Parents
Republic of Korea
/ epidemiology
Risk Factors
Self Report
Smoking
/ adverse effects
Surveys and Questionnaires
Tobacco Smoke Pollution
/ adverse effects
Asthma
Child
Cotinine
Parents
Smoke
Tobacco Smoke Pollution
Journal
Journal of Korean medical science
ISSN: 1598-6357
Titre abrégé: J Korean Med Sci
Pays: Korea (South)
ID NLM: 8703518
Informations de publication
Date de publication:
02 Aug 2021
02 Aug 2021
Historique:
received:
12
02
2021
accepted:
22
06
2021
entrez:
3
8
2021
pubmed:
4
8
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Environmental tobacco smoke exposure due to parents is a modifiable risk factor for childhood asthma, but many studies have evaluated parental smoking using self-reported data. Therefore, we aimed to analyze the relationship between parental cotinine-verified smoking status and asthma in their children. This population-based cross-sectional study used data from the Korean National Health and Nutrition Examination Survey from 2014 to 2017. Participants aged 0 to 18 years with complete self-reported physician-diagnosed childhood asthma and measurement of their parental urinary cotinine levels were included. Parental urinary cotinine-verified smoking status was defined using both urinary cotinine levels and self-report, as active, passive, and non-smoker. Sample weights were applied to all statistical analyses because of a complex, multistage and clustered survey design. Logistic regression model was used to analyze the relationship between childhood asthma and parental smoking. A total of 5,264 subjects aged < 19 years were included. The prevalence of asthma was 3.4%. The proportions of paternal and maternal urinary cotinine-verified active smokers during the study period were 50.4% and 16.9%, respectively. When parental urinary cotinine level increased, the proportion of parental low household income was increased ( There seems to be a dose-related association between paternal urinary cotinine levels and the risk of childhood asthma. Because of the high rate of paternal smoking, further studies are needed to develop a targeted strategy to reduce parental smoking for childhood asthma.
Sections du résumé
BACKGROUND
BACKGROUND
Environmental tobacco smoke exposure due to parents is a modifiable risk factor for childhood asthma, but many studies have evaluated parental smoking using self-reported data. Therefore, we aimed to analyze the relationship between parental cotinine-verified smoking status and asthma in their children.
METHODS
METHODS
This population-based cross-sectional study used data from the Korean National Health and Nutrition Examination Survey from 2014 to 2017. Participants aged 0 to 18 years with complete self-reported physician-diagnosed childhood asthma and measurement of their parental urinary cotinine levels were included. Parental urinary cotinine-verified smoking status was defined using both urinary cotinine levels and self-report, as active, passive, and non-smoker. Sample weights were applied to all statistical analyses because of a complex, multistage and clustered survey design. Logistic regression model was used to analyze the relationship between childhood asthma and parental smoking.
RESULTS
RESULTS
A total of 5,264 subjects aged < 19 years were included. The prevalence of asthma was 3.4%. The proportions of paternal and maternal urinary cotinine-verified active smokers during the study period were 50.4% and 16.9%, respectively. When parental urinary cotinine level increased, the proportion of parental low household income was increased (
CONCLUSION
CONCLUSIONS
There seems to be a dose-related association between paternal urinary cotinine levels and the risk of childhood asthma. Because of the high rate of paternal smoking, further studies are needed to develop a targeted strategy to reduce parental smoking for childhood asthma.
Identifiants
pubmed: 34342184
pii: 36.e193
doi: 10.3346/jkms.2021.36.e193
pmc: PMC8329391
doi:
Substances chimiques
Tobacco Smoke Pollution
0
Cotinine
K5161X06LL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e193Subventions
Organisme : College of Medicine, Koisin University
Pays : Korea
Organisme : National Research Foundation of Korea
ID : 2020R1F1A1068115
Pays : Korea
Informations de copyright
© 2021 The Korean Academy of Medical Sciences.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
Références
Nicotine Tob Res. 2017 Mar 1;19(3):282-289
pubmed: 27613884
J Allergy Clin Immunol. 2014 Sep;134(3):499-507
pubmed: 25171864
Eur Respir J. 2020 Dec 24;56(6):
pubmed: 32972987
Sci Rep. 2020 Oct 2;10(1):16409
pubmed: 33009485
Front Cell Dev Biol. 2020 Feb 05;8:38
pubmed: 32117969
Respir Res. 2010 Jan 29;11:11
pubmed: 20113468
BMC Public Health. 2020 Aug 8;20(1):1210
pubmed: 32770990
Lancet. 2018 Jan 27;391(10118):350-400
pubmed: 28911920
Ann Allergy Asthma Immunol. 2015 Nov;115(5):396-401.e2
pubmed: 26411971
PLoS One. 2014 Nov 14;9(11):e112690
pubmed: 25397875
J Immunol. 2001 Oct 15;167(8):4765-70
pubmed: 11591808
Allergy. 2009 Mar;64(3):398-405
pubmed: 19120070
Int J Epidemiol. 2014 Feb;43(1):69-77
pubmed: 24585853
J Allergy Clin Immunol. 2005 Dec;116(6):1213-9
pubmed: 16337448
J Allergy Clin Immunol. 2014 Jun;133(6):1572-8.e3
pubmed: 24495434
Tob Control. 2006 Aug;15(4):294-301
pubmed: 16885578
Thorax. 2008 Feb;63(2):172-6
pubmed: 18089631
Environ Int. 2018 Dec;121(Pt 1):643-648
pubmed: 30316179
Int Arch Allergy Immunol. 2008;146(1):57-65
pubmed: 18087162
Front Pediatr. 2019 Jun 18;7:246
pubmed: 31275909
Am J Prev Med. 2017 Oct;53(4):441-448
pubmed: 28532658
Addiction. 2015 Sep;110(9):1484-92
pubmed: 26061741
J Environ Health Sci. 2016;2(6):
pubmed: 29399637
J Allergy Clin Immunol. 2008 Dec;122(6):1208-14
pubmed: 18926564
Cochrane Database Syst Rev. 2008 Oct 08;(4):CD001746
pubmed: 18843622
J Allergy Clin Immunol. 2010 Aug;126(2):187-97; quiz 198-9
pubmed: 20688204
Korean J Fam Med. 2020 Jan;41(1):3-13
pubmed: 31189304
BMC Public Health. 2016 Jun 08;16:485
pubmed: 27277721
Eur Respir J. 2013 May;41(5):1189-99
pubmed: 22903968
Immunity. 2015 Mar 17;42(3):566-79
pubmed: 25786179
Thorax. 2012 Nov;67(11):941-9
pubmed: 22693180
ERJ Open Res. 2016 Jul 29;2(3):
pubmed: 27730206
Soc Sci Med. 1991;32(9):989-1005
pubmed: 2047903
Environ Toxicol Pharmacol. 2009 Jul;28(1):92-6
pubmed: 21783987
Mucosal Immunol. 2009 May;2(3):206-19
pubmed: 19262504
Pediatr Pulmonol. 2015 Apr;50(4):353-62
pubmed: 24648197
Lancet Respir Med. 2017 Mar;5(3):224-234
pubmed: 27666650
Nicotine Tob Res. 2009 Jan;11(1):12-24
pubmed: 19246437
J Allergy Clin Immunol. 2005 Jan;115(1):61-6
pubmed: 15637548
Am J Respir Crit Care Med. 2001 Feb;163(2):429-36
pubmed: 11179118
J Korean Med Sci. 2010 May;25(5):752-7
pubmed: 20436713
Lancet. 2008 Sep 20;372(9643):1058-64
pubmed: 18805334
Sci Total Environ. 2016 Jan 15;542(Pt A):144-52
pubmed: 26519575
J Allergy Clin Immunol. 2006 Nov;118(5):1040-7
pubmed: 17088127
Am J Respir Cell Mol Biol. 2009 Jan;40(1):38-46
pubmed: 18635815
J Pediatr (Rio J). 2019 Sep - Oct;95(5):506-508
pubmed: 30590013
J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1111-1122
pubmed: 27286779
J Pediatr. 2012 Jun;160(6):1050-1
pubmed: 22494871
J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):201-7
pubmed: 24607049
Korean J Fam Med. 2016 May;37(3):171-6
pubmed: 27274388
Pediatrics. 2014 Sep;134(3):428-34
pubmed: 25136039
Environ Res. 2018 Oct;166:35-41
pubmed: 29859939
Nicotine Tob Res. 2020 Jun 12;22(7):1086-1097
pubmed: 31570931