Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF.
Charcot Marie Tooth
EHD
LITAF
Rab11
Recycling endosome
SNX
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
received:
15
02
2021
accepted:
16
06
2021
entrez:
3
8
2021
pubmed:
4
8
2021
medline:
27
10
2021
Statut:
ppublish
Résumé
Recycling to the cell surface requires the scission of tubular membrane intermediates emanating from endosomes. Here, we identify the monotopic membrane protein LPS-induced TNF-activating factor (LITAF) and the related protein cell death involved p53 target 1 (CDIP1) as novel membrane curvature proteins that contribute to recycling tubule scission. Recombinant LITAF supports high membrane curvature, shown by its ability to reduce proteoliposome size. The membrane domains of LITAF and CDIP1 partition strongly into ∼50 nm diameter tubules labelled with the recycling markers Pacsin2, ARF6 and SNX1, and the recycling cargoes MHC class I and CD59. Partitioning of LITAF into tubules is impaired by mutations linked to Charcot Marie Tooth disease type 1C. Meanwhile, co-depletion of LITAF and CDIP1 results in the expansion of tubular recycling compartments and stabilised Rab11 tubules, pointing to a function for LITAF and CDIP1 in membrane scission. Consistent with this, co-depletion of LITAF and CDIP1 impairs integrin recycling and cell migration.
Identifiants
pubmed: 34342350
pii: 271100
doi: 10.1242/jcs.258549
pmc: PMC8353527
pii:
doi:
Substances chimiques
Integrins
0
LITAF protein, human
0
Lipopolysaccharides
0
Membrane Proteins
0
Nuclear Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 212246/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701140
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203995/Z/16/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M000877/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
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