Physiological and motion signatures in static and time-varying functional connectivity and their subject identifiability.
fMRI
functional connectivity
head motion
human
neuroscience
physiological processes
resting-state
time-varying functional connectivity
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
21
08
2020
accepted:
02
08
2021
pubmed:
4
8
2021
medline:
24
9
2021
entrez:
3
8
2021
Statut:
epublish
Résumé
Human brain connectivity yields significant potential as a noninvasive biomarker. Several studies have used fMRI-based connectivity fingerprinting to characterize individual patterns of brain activity. However, it is not clear whether these patterns mainly reflect neural activity or the effect of physiological and motion processes. To answer this question, we capitalize on a large data sample from the Human Connectome Project and rigorously investigate the contribution of the aforementioned processes on functional connectivity (FC) and time-varying FC, as well as their contribution to subject identifiability. We find that head motion, as well as heart rate and breathing fluctuations, induce artifactual connectivity within distinct resting-state networks and that they correlate with recurrent patterns in time-varying FC. Even though the spatiotemporal signatures of these processes yield above-chance levels in subject identifiability, removing their effects at the preprocessing stage improves identifiability, suggesting a neural component underpinning the inter-individual differences in connectivity.
Identifiants
pubmed: 34342582
doi: 10.7554/eLife.62324
pii: 62324
pmc: PMC8378847
doi:
pii:
Banques de données
figshare
['10.6084/m9.figshare.c.5472591.v1']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Informations de copyright
© 2021, Xifra-Porxas et al.
Déclaration de conflit d'intérêts
AX, MK, GM No competing interests declared
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