Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.
atrophy
disuse
gene network analysis
muscle protein synthesis
skeletal muscle
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
05
07
2021
received:
15
02
2021
accepted:
19
07
2021
entrez:
3
8
2021
pubmed:
4
8
2021
medline:
24
8
2021
Statut:
ppublish
Résumé
Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates that quantitatively link to the degree of muscle atrophy and/or extent of decline in MPS during short-term disuse in humans. After consuming a bolus dose of deuterium oxide (D
Identifiants
pubmed: 34342902
doi: 10.1096/fj.202100276RR
doi:
Substances chimiques
Muscle Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21830Subventions
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/J014400/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M009122/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/N015894/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/P021220/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/R502364/1
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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